Description

(S)-Rasagiline Mesylate is a high-purity, enantiomerically pure active pharmaceutical ingredient (API) and key synthetic intermediate. It serves as the critical chiral building block for the production of Rasagiline, a potent and selective monoamine oxidase-B (MAO-B) inhibitor used in the treatment of Parkinson's disease. This compound is essential for pharmaceutical manufacturers and advanced research institutions engaged in neurology-focused drug development and synthesis.

Application

• Pharmaceutical API Synthesis: Primary use as the direct precursor in the commercial manufacturing of Rasagiline mesylate API.
• Neurological Research: Critical intermediate in R&D for developing novel MAO-B inhibitors and studying Parkinson's disease mechanisms.
• Process Chemistry & Scale-Up: Used in process optimization, route scouting, and pilot-scale production for pharmaceutical projects.
• Reference Standard: Serves as a high-purity chemical reference standard for analytical method development and quality control (QC) testing.
• Asymmetric Synthesis: Valuable chiral synthon for the synthesis of other complex molecules requiring the (S)-1-aminoindan scaffold.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production of finished dosage forms.

Basic Information

Product Name	(S)-Rasagiline Mesylate
CAS No.	202464-89-9
Molecular Formula	C12H13N • CH4O3S
Molecular Weight	267.34 g/mol
Synonyms	(S)-N-Propargyl-1-aminoindan mesylate; (S)-Rasagiline methanesulfonate; (S)-AG-1135; (S)-TVP-1012; (S)-1-Aminoindan, N-2-propynyl-, methanesulfonate; (S)-2,3-Dihydro-N-2-propynyl-1H-inden-1-amine methanesulfonate; (R)-(-)-Rasagiline Mesylate (enantiomer); Azilect Intermediate
EINECS	Contact for details

Quality Control

Our (S)-Rasagiline Mesylate is manufactured under strict quality management systems. Each batch is tested to ensure compliance with high-purity standards suitable for pharmaceutical R&D and API synthesis. Specifications typically cover identity, purity (by HPLC), chiral purity, residual solvents, and related substances. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing all test results against predefined acceptance criteria.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.5%
Chiral Purity (HPLC)	≥99.0% (S)-enantiomer
Related Substances (HPLC)	Total impurities ≤1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.