Description

Guanfacine Hcl CAS NO 29520-14-7 is a high-purity pharmaceutical active ingredient, specifically an α-2A adrenergic receptor agonist. It is a critical intermediate and active pharmaceutical ingredient (API) used in the synthesis of finished dosage forms for the treatment of hypertension and attention deficit hyperactivity disorder (ADHD). This compound is essential for pharmaceutical manufacturers, research institutions, and contract development and manufacturing organizations (CDMOs) engaged in central nervous system (CNS) and cardiovascular drug development.

Application

• Pharmaceutical API: Primary use as the active ingredient in the manufacture of prescription medications for hypertension and ADHD.
• Generic Drug Formulation: Serves as a key component in the development and production of generic versions of branded guanfacine hydrochloride drugs.
• Clinical Research Material: Used as a reference standard and raw material in preclinical and clinical trials for new therapeutic applications.
• Controlled-Release Formulations: Incorporated into advanced drug delivery systems, such as extended-release tablets, to provide sustained therapeutic effect.
• Pharmacological Studies: Employed in laboratory research to study α-2 adrenergic receptor mechanisms and related neurological pathways.
• CDMO & CMO Supply: Supplied to contract manufacturing organizations for scale-up and commercial batch production under cGMP guidelines.

Basic Information

Product Name	Guanfacine Hcl
CAS No.	29520-14-7
Molecular Formula	C9H9Cl2N3O•HCl
Molecular Weight	282.55 g/mol
Synonyms	Guanfacine Hydrochloride; 1-(2,6-Dichlorophenyl)acetyl]guanidine hydrochloride; BW-430C; Estulic; Tenex; Intuniv; N-Amidino-2-(2,6-dichlorophenyl)acetamide hydrochloride; 2-[(2,6-Dichlorophenyl)acetyl]guanidine hydrochloride
EINECS	Contact for details

Quality Control

Our Guanfacine Hydrochloride is manufactured and tested to meet stringent pharmaceutical standards. Quality is assured through a comprehensive analytical control strategy that includes identity, purity, and impurity profile testing. We provide full traceability and support regulatory filings with detailed documentation. Certificates of Analysis (COA) are available upon request, confirming compliance with relevant pharmacopeial monographs (e.g., USP, EP) and in-house specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and should be handled in a low-humidity environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	NMT 1.0%
Residue on Ignition	NMT 0.1%
Heavy Metals	NMT 20 ppm
Related Substances (HPLC)	Total impurities: NMT 1.0% Any individual impurity: NMT 0.5%
Microbial Limits	Meets Ph. Eur. 2.6.12 / USP <61> requirements

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.