Description

Methyl (1S,2S,3S,5R)-8-Methyl-3-(Phenylcarbamoyloxy)-8-Azabicyclo[3.2.1]Octane-2-Carboxylate Hydrochloride is a high-purity, stereochemically defined pharmaceutical intermediate and research chemical. This compound is critical for the synthesis and development of active pharmaceutical ingredients (APIs) targeting the central nervous system, particularly as a key precursor for tropane alkaloid derivatives. It is primarily utilized by pharmaceutical R&D laboratories, process development chemists, and manufacturers specializing in complex, chirally-pure molecules for therapeutic applications.

Application

• Pharmaceutical Intermediate: A crucial building block in the multi-step synthesis of novel pharmaceutical agents, especially those with neurological activity.
• Active Pharmaceutical Ingredient (API) Development: Serves as a core structural moiety for the research and development of new drug candidates.
• Neurological Research: Used in preclinical studies to investigate compounds that interact with neurotransmitter systems, given its tropane-related structure.
• Process Chemistry & Scale-Up: Employed in optimizing synthetic routes from laboratory scale to pilot and commercial manufacturing.
• Reference Standard: Provides a high-purity standard for analytical method development, validation, and quality control in pharmaceutical analysis.
• Asymmetric Synthesis: Utilized in chiral synthesis due to its defined (1S,2S,3S,5R) stereochemistry, enabling the construction of complex, enantiomerically pure molecules.

Basic Information

Product Name	Methyl (1S,2S,3S,5R)-8-Methyl-3-(Phenylcarbamoyloxy)-8-Azabicyclo[3.2.1]Octane-2-Carboxylate Hydrochloride
CAS No.	29364-13-4
Molecular Formula	C18H24N2O4 • HCl
Molecular Weight	368.86 g/mol (Free base: 332.40 g/mol)
Synonyms	3β-Hydroxytropane-2β-carboxylic acid methyl ester phenylcarbamate hydrochloride; Tropane-3-ol, 2-carboxylic acid methyl ester, phenylcarbamate (ester), hydrochloride, (1R,2R,3S,5S)-; Methyl 8-methyl-3-[(phenylamino)carbonyl]oxy]-8-azabicyclo[3.2.1]octane-2-carboxylate hydrochloride; Phenylcarbamic acid (1S,2S,3S,5R)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester, 2-methyl ester, hydrochloride; Tropine phenylcarbamate methyl ester hydrochloride; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our Methyl (1S,2S,3S,5R)-8-Methyl-3-(Phenylcarbamoyloxy)-8-Azabicyclo[3.2.1]Octane-2-Carboxylate Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed and desiccated to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% (1S,2S,3S,5R)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%; Any single impurity ≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.