Description

Guanfacine Hcl CAS NO 29110-48-3 is a high-purity pharmaceutical active ingredient, chemically known as N-amidino-2-(2,6-dichlorophenyl)acetamide hydrochloride. This compound is a selective α-2A adrenergic receptor agonist, valued for its central nervous system activity. It is primarily required by pharmaceutical manufacturers and research institutions for the formulation of medications and advanced clinical studies.

Application

• Pharmaceutical API: Core active ingredient in the manufacture of prescription medications for hypertension and attention deficit hyperactivity disorder (ADHD).
• Neurological Research: Used in preclinical and clinical studies investigating central α-2 adrenoceptor mechanisms and related neurological pathways.
• Formulation Development: Serves as a reference standard and key component in the development of various dosage forms, including extended-release tablets.
• Generic Drug Production: Essential for companies producing bioequivalent generic versions of branded guanfacine hydrochloride drugs.
• Analytical Standard: High-purity material used for quality control, method validation, and calibration in analytical laboratories (HPLC, GC).
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP-compliant drug product manufacturing.

Basic Information

Product Name	Guanfacine Hydrochloride
CAS No.	29110-48-3
Molecular Formula	C9H9Cl2N3O·HCl
Molecular Weight	282.55 g/mol
Synonyms	Guanfacine HCl; Guanfacine Hydrochloride; BW-430C; N-Amidino-2-(2,6-dichlorophenyl)acetamide Hydrochloride; 2-[(2,6-Dichlorophenyl)acetyl]guanidine Hydrochloride; Tenex (brand name); Intuniv (brand name, extended-release); Estulic
EINECS	Contact for details

Quality Control

Our Guanfacine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for pharmaceutical use, including identity, purity, and impurity profiles. Certificates of Analysis (COA) are provided, detailing results against relevant pharmacopeial standards (such as USP/EP) and in-house specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.