Description

S-(-)-Carbidopa is the pharmacologically active enantiomer of carbidopa, a crucial aromatic amino acid decarboxylase inhibitor. Its primary value lies in its stereospecific activity, which is essential for enhancing the efficacy and reducing the side effects of L-DOPA therapy in Parkinson's disease. This high-purity chiral intermediate is critically needed by pharmaceutical manufacturers and advanced research institutions developing and producing next-generation neurological therapeutics and conducting enantioselective synthesis studies.

Application

• Active Pharmaceutical Ingredient (API): A key enantiopure component in the formulation of advanced Parkinson's disease medications, often used in combination with L-DOPA.
• Pharmaceutical Intermediate: Serves as a critical chiral building block in the synthetic pathways for novel neuroactive drugs and prodrugs.
• Research & Development: Used in biochemical and pharmacological studies to investigate dopaminergic pathways, enzyme inhibition kinetics, and stereochemistry effects.
• Reference Standard: Employed as a high-purity calibration standard in analytical laboratories for quality control (HPLC, GC) and method development.
• Enantioselective Synthesis: Utilized as a starting material or template in asymmetric synthesis for creating other chiral molecules with potential therapeutic value.

Basic Information

Product Name	S-(-)-Carbidopa
CAS No.	28860-95-9
Molecular Formula	C10H14N2O4 • H2O
Molecular Weight	244.24 g/mol (Anhydrous)
Synonyms	(-)-L-α-Hydrazino-3,4-dihydroxy-α-methylbenzenepropanoic Acid Monohydrate; (S)-(-)-Carbidopa; Levocarbidopa; L-Carbidopa; (2S)-3-(3,4-Dihydroxyphenyl)-2-hydrazino-2-methylpropanoic Acid; MK-486; NSC-263475
EINECS	Contact for details

Quality Control

Our S-(-)-Carbidopa is manufactured and tested under strict quality management systems. We ensure compliance with relevant pharmaceutical-grade specifications, and the product is supported by a comprehensive Certificate of Analysis (COA) that details purity, enantiomeric excess, and impurity profiles. Batches are routinely analyzed using advanced chromatographic (HPLC, chiral HPLC) and spectroscopic methods to guarantee identity, potency, and consistency, meeting the stringent requirements of API production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider using a desiccant.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Enantiomeric Purity (Chiral HPLC)	≥99.0%
Water Content (KF)	≤7.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤1.5% Any single impurity ≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.