Description

Poly-5-Bromouridylic Acid is a synthetic polynucleotide derivative where the uracil base is modified with a bromine atom at the 5-position. This modification is critical for its role as a biochemical tool in molecular biology and pharmaceutical research. It is primarily utilized by research institutions, diagnostic kit manufacturers, and biotechnology companies engaged in nucleic acid studies and therapeutic development.

Application

• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies involving polymerases and nucleases to investigate nucleic acid metabolism and function.
• Antiviral & Anticancer Research: Serves as a key intermediate or analog in the development of nucleoside-based prodrugs and therapeutic agents targeting viral replication or cancer cell proliferation.
• Diagnostic Probe Development: Employed in the synthesis of labeled probes for hybridization assays, where the bromine atom can serve as a handle for further conjugation or detection.
• Structural Biology Studies: Incorporated into oligonucleotides for X-ray crystallography or NMR studies to understand nucleic acid structure and ligand interactions.
• RNAi & Oligonucleotide Therapeutics: Acts as a modified building block to enhance the stability, binding affinity, or pharmacokinetic properties of therapeutic oligonucleotides.

Basic Information

Product Name	Poly-5-Bromouridylic Acid
CAS No.	27988-64-3
Molecular Formula	(C9H11BrN2O9P)n
Molecular Weight	Contact for details
Synonyms	Poly(5-bromouridylic acid); 5-Bromo-UMP Polymer; Poly(5-BrU); Brominated Poly(U); Poly(5-bromouridine 5'-monophosphate); 5-Bromouridylic Acid Homopolymer; Poly(5-bromo-1-β-D-ribofuranosyluracil 5'-phosphate)
EINECS	Contact for details

Quality Control

Our Poly-5-Bromouridylic Acid is produced under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and other critical parameters. We adhere to ISO 9001 quality management principles, and our quality systems support compliance with cGMP standards for research-grade materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This material is hygroscopic (moisture-sensitive) and light-sensitive; ensure the container is kept sealed in a desiccated environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
5-Bromouridine Content	≥ 85% (by UV)
Moisture Content (KF)	≤ 5.0%
Endotoxin Level	< 10 EU/mg (if applicable)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.