Description

Polyuridylic Acid Potassium Salt is a synthetic, single-stranded homopolymer of uridylic acid, where the phosphate groups are complexed with potassium ions. This compound is a critical biochemical reagent, valued for its role as a template in molecular biology research and as a standard in nucleic acid analysis. It is primarily utilized by research institutions, diagnostic kit manufacturers, and pharmaceutical companies engaged in virology, enzymology, and the development of mRNA-based technologies.

Application

• Molecular Biology Research: Used as a synthetic mRNA template in studies of translation, RNA polymerase activity, and ribosome function.
• Diagnostic Assay Development: Serves as a critical component and control in the development of kits for viral detection and nucleic acid amplification techniques.
• Enzymology Studies: Acts as a substrate for enzymes such as ribonucleases, polynucleotide phosphorylase, and reverse transcriptase to study kinetics and inhibition.
• Biochemical Standard: Employed as a calibration standard in chromatographic (HPLC) and spectroscopic methods for nucleic acid quantification and purity assessment.
• Vaccine & Therapeutic Research: Used in preliminary research for mRNA vaccine platforms and oligonucleotide-based therapies to model poly-U tail structures.
• Polymer Chemistry: Functions as a model compound for studying the physical and chemical properties of polynucleotides.

Basic Information

Product Name	Polyuridylic Acid Potassium Salt
CAS No.	27416-86-0
Molecular Formula	(C9H11KN2O9P)n
Molecular Weight	Variable (polymer)
Synonyms	Poly(U) Potassium Salt; Potassium Polyuridylate; Polyuridylic Acid, K Salt; Poly(U)•K+; 5'-Polyuridylic Acid Potassium Salt; Polynucleotidyltransferase Uridine 5'-Triphosphate Uridylyltransferase Polymer; Polyuridylic Acid Homopolymer Potassium Salt
EINECS	Contact for details

Quality Control

Every batch of our Polyuridylic Acid Potassium Salt is manufactured and tested under stringent quality management systems. We provide comprehensive analytical data to ensure product integrity for sensitive research applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as absorbance ratios, chain length, and biological activity. Our quality commitment aligns with the standards expected in GMP-like environments for research-grade biochemicals.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This material is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and moisture uptake. For short-term use, store desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder or lyophilized solid
Identification (UV-Vis)	Characteristic absorbance spectrum of poly(U)
A260/A280 Ratio	≥ 2.0
Assay (HPLC)	≥ 95% (Polyuridylic Acid content)
Chain Length (Sizing)	Available in specific ranges (e.g., 100-500, 500-2000 nucleotides)
Potassium Content (ICP)	Consistent with theoretical value
Endotoxin (LAL)	< 10 EU/mg (for research-grade)
Solubility	Soluble in aqueous buffers, TE buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.