Description

2-[[(2S,5β)-3,3-Dimethyl-7-Oxo-6α-[(2-Phenylacetyl)Amino]-4-Thia-1-Azabicyclo[3.2.0]Heptan-2β-Yl]Carbonyl]-3-Oxo-2,3-Dihydro-1,2-Benzisothiazole 1,1-Dioxide is a high-purity advanced pharmaceutical intermediate, also known as a key derivative in the synthesis of certain β-lactam antibiotics. Its precise stereochemistry and functional groups make it a critical building block for research and development in novel antimicrobial agents. This compound is primarily required by pharmaceutical manufacturers and contract research organizations (CROs) focused on developing next-generation therapeutic compounds.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of novel β-lactam antibiotic candidates and related active pharmaceutical ingredients (APIs).
• Antimicrobial Research: Used in R&D laboratories for structure-activity relationship (SAR) studies to develop new compounds with enhanced efficacy against resistant bacterial strains.
• Process Chemistry Development: Employed in scaling up and optimizing synthetic routes for complex heterocyclic molecules within pilot plants.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.
• Academic Research: Utilized in university and institutional labs for advanced studies in organic synthesis and medicinal chemistry.

Basic Information

Product Name	2-[[(2S,5β)-3,3-Dimethyl-7-Oxo-6α-[(2-Phenylacetyl)Amino]-4-Thia-1-Azabicyclo[3.2.0]Heptan-2β-Yl]Carbonyl]-3-Oxo-2,3-Dihydro-1,2-Benzisothiazole 1,1-Dioxide
CAS No.	27255-81-8
Molecular Formula	C24H21N3O6S2
Molecular Weight	511.57 g/mol
Synonyms	6β-(Phenylacetamido)penicillanic acid 1,1-dioxide benzisothiazolone derivative; (2S,5R,6R)-6-[(2-Phenylacetamido)]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 1,1-dioxide benzisothiazolone; Penicillin G derivative benzisothiazolone; 6-APA derivative sulfone; 27255-81-8; 6β-Phenylacetamidopenicillanic acid sulfone benzisothiazolone
EINECS	Contact for details

Quality Control

Our 2-[[(2S,5β)-3,3-Dimethyl-7-Oxo-6α-[(2-Phenylacetyl)Amino]-4-Thia-1-Azabicyclo[3.2.0]Heptan-2β-Yl]Carbonyl]-3-Oxo-2,3-Dihydro-1,2-Benzisothiazole 1,1-Dioxide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical intermediates. Certificates of Analysis (COA) detailing batch-specific results are available upon request. We support compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.