Description

Poly(2'-o-Methylcytidylic Acid) is a synthetic, chemically modified polynucleotide, specifically a homopolymer of 2'-O-methylcytidine monophosphate. This modification confers significant nuclease resistance and enhanced stability compared to its unmodified RNA counterpart, making it a critical tool for advanced molecular biology and therapeutic research. It is primarily utilized by research institutions and biotechnology companies engaged in oligonucleotide therapeutics, antisense technology, and the development of stable RNA analogs. The compound is supplied with a guaranteed Certificate of Analysis to ensure batch-to-batch consistency for sensitive applications.

Application

• Oligonucleotide Therapeutics: Serves as a nuclease-resistant building block for antisense oligonucleotides (ASOs) and siRNA constructs to enhance in vivo stability and efficacy.
• Molecular Biology Research: Used as a model compound to study RNA structure, function, and protein-RNA interactions where enhanced stability is required.
• Diagnostic Probe Development: Employed in the synthesis of stable hybridization probes for sensitive detection assays, including FISH and microarray technologies.
• Pharmaceutical Intermediate: Acts as a key raw material in the synthesis and scale-up of novel RNA-based drug candidates under GMP conditions.
• Biochemical Reagent: Utilized as a substrate or inhibitor in enzymatic studies involving nucleases, polymerases, and other nucleic acid-modifying enzymes.

Basic Information

Product Name	Poly(2'-o-Methylcytidylic Acid)
CAS No.	27014-37-5
Molecular Formula	(C10H14N3O7P)n
Molecular Weight	319.21 (monomer)
Synonyms	Poly(2'-O-methylcytidylic acid); 2'-O-Methylpoly(C); Poly(2'-O-methylcytidylate); Poly(2'-O-Me-C); 2'-O-Methylcytidine homopolymer; Poly(2'-O-methylcytidine 5'-monophosphate); Poly(m2C); PMeC
EINECS	Contact for details

Quality Control

Our Poly(2'-o-Methylcytidylic Acid) is manufactured under stringent quality systems to ensure it meets the exacting requirements of life science research and pharmaceutical development. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as purity, chain length, and endotoxin levels. We adhere to relevant industry standards and can support development projects requiring material manufactured under GMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This material is hygroscopic (moisture-sensitive). Allow the sealed container to reach room temperature before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95% (Polymer Content)
Chain Length (n)	10 - 30 (Contact for specific distribution)
Endotoxin	< 10 EU/mg
Solubility	Soluble in water, TE buffer
Moisture (KF)	< 5.0 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.