Description

Polyadenylic Acid (5') Potassium Salt is a synthetic, single-stranded homopolymer of adenosine monophosphate, widely utilized as a critical reagent in molecular biology and biochemistry. Its consistent quality and defined structure make it an essential tool for researchers and manufacturers requiring reliable nucleic acid standards and hybridization controls. This product is primarily used by the biotechnology, pharmaceutical, and diagnostic industries for applications such as mRNA research, enzyme calibration, and as a model substrate for studying RNA-protein interactions.

Application

• Molecular Biology Research: Used as a standard, control, or substrate in enzymatic assays, including for poly(A) polymerase and reverse transcriptase.
• mRNA Studies: Serves as a model poly(A) tail for investigating mRNA stability, translation, and degradation pathways.
• Diagnostic Assay Development: Employed in the development and calibration of nucleic acid-based diagnostic kits and hybridization protocols.
• Biochemical Reagent: Acts as a primer or template in various in vitro transcription and amplification systems.
• Pharmaceutical R&D: Used in screening assays for drug candidates targeting RNA-binding proteins or viral replication cycles.
• Quality Control: Functions as a reference material for quality assurance in oligonucleotide synthesis and analysis laboratories.

Basic Information

Product Name	Polyadenylic Acid (5') Potassium Salt
CAS No.	26763-19-9
Molecular Formula	(C10H12KN5O7P)n
Molecular Weight	Contact for details (Polymer)
Synonyms	Poly(A) Potassium Salt; Polyadenylate Potassium Salt; Polyadenylic Acid Potassium Salt; 5'-Polyadenylic Acid Potassium Salt; Poly rA Potassium Salt; Potassium Polyadenylate; Poly A; Adenosine 5'-monophosphate polymer potassium salt
EINECS	Contact for details

Quality Control

Our Polyadenylic Acid (5') Potassium Salt is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for life science research. Certificates of Analysis (COA) detailing specific parameters such as absorbance ratios, melting temperature (Tm), and chain length distribution are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This material is hygroscopic (moisture-sensitive). For long-term storage, desiccate at -20°C. Allow the container to reach room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (UV-Vis)	Characteristic spectrum of polyadenylic acid
A260/A280 Ratio	≥ 2.0
Assay (HPLC)	≥ 95% (Poly(A) content)
pH (1% Solution)	6.0 - 8.0
Endotoxin	< 10 EU/mg (if specified)
Solubility	Soluble in water, slightly soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.