Description

5-(Trifluoromethyl)Isobenzofuran-1,3-Dione is a high-value fluorinated organic building block, specifically a trifluoromethyl-substituted phthalic anhydride derivative. Its core value lies in introducing the highly desirable trifluoromethyl group into complex molecules, imparting enhanced metabolic stability, lipophilicity, and bioavailability. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries seeking to develop novel active ingredients with improved properties.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of drugs targeting central nervous system (CNS) disorders, anti-inflammatory agents, and oncology therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the CF3 group can enhance biological activity and environmental persistence.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the synthesis of specialized polymers, such as polyimides, offering potential for high-performance materials with unique thermal and chemical resistance.
• Ligand and Catalyst Development: Employed in organic chemistry research to create novel ligands and organocatalysts that leverage the electron-withdrawing nature of the trifluoromethyl group.
• Fluorinated Dye and Pigment Intermediate: Acts as a building block for synthesizing fluorinated dyes and pigments, which can exhibit superior light fastness and color properties.

Basic Information

Product Name	5-(Trifluoromethyl)Isobenzofuran-1,3-Dione
CAS No.	26238-14-2
Molecular Formula	C9H3F3O3
Molecular Weight	216.11 g/mol
Synonyms	4-(Trifluoromethyl)phthalic anhydride; 5-(Trifluoromethyl)phthalic anhydride; 1,3-Isobenzofurandione, 5-(trifluoromethyl)-; 4-Trifluoromethylphthalic anhydride; 5-Trifluoromethylphthalic anhydride; 4-Carboxy-2-(trifluoromethyl)benzoic acid anhydride; Trifluoromethylphthalic anhydride
EINECS	Contact for details

Quality Control

Our 5-(Trifluoromethyl)Isobenzofuran-1,3-Dione is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via FT-IR and NMR, to ensure it meets exacting standards for research and development use. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation by atmospheric moisture. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.