Description

4-(Trifluoromethyl)Benzoic Anhydride is a high-purity fluorinated organic building block essential for advanced chemical synthesis. This compound is valued for its role in introducing the robust and lipophilic trifluoromethylphenyl moiety into target molecules, significantly altering their physicochemical properties. It is a critical intermediate for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty materials sectors seeking to develop novel compounds with enhanced metabolic stability, bioavailability, and performance.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring the trifluoromethyl group for improved drug-like properties.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides where the trifluoromethyl group enhances biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the manufacture of fluorinated components for electronic displays and organic light-emitting diodes (OLEDs).
• Polymer & Resin Modifier: Incorporated into specialty polymers to impart unique characteristics such as chemical resistance, thermal stability, and altered surface properties.
• Organic Synthesis Reagent: Employed as an acylating agent in academic and industrial research laboratories for the preparation of esters, amides, and other derivatives.
• Dye & Pigment Manufacturing: Used in the synthesis of complex, high-performance fluorinated dyes and pigments.

Basic Information

Product Name	4-(Trifluoromethyl)Benzoic Anhydride
CAS No.	25753-16-6
Molecular Formula	C16H8F6O3
Molecular Weight	362.23 g/mol
Synonyms	alpha,alpha,α-Trifluoro-p-toluic anhydride; 4-(Trifluoromethyl)benzoic acid anhydride; Bis[4-(trifluoromethyl)benzoyl] oxide; p-(Trifluoromethyl)benzoic anhydride; 4-(Trifluoromethyl)benzoyl anhydride; TFBA; Anhydrid kyseliny 4-(trifluormethyl)benzoovej
EINECS	Contact for details

Quality Control

Our 4-(Trifluoromethyl)Benzoic Anhydride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and FTIR, to ensure high chemical purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	95 - 100 °C
Loss on Drying	≤ 0.5%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.