Description

Polycytidylic-Polyguanylic Acid Sodium is a synthetic, double-stranded RNA polymer composed of cytidylic and guanylic acid residues. This compound is a critical research tool and pharmaceutical intermediate, primarily valued for its potent immunostimulatory properties as a Toll-like receptor (TLR) agonist. It is essential for researchers and manufacturers in the biotechnology and pharmaceutical sectors, particularly those developing vaccine adjuvants, antiviral agents, and immunotherapies.

Application

• Vaccine Adjuvant Development: Used as a potent immunostimulant to enhance the efficacy of prophylactic and therapeutic vaccines.
• Immunology & Cancer Research: Serves as a standard TLR3 and MDA5 agonist to study innate immune response pathways and evaluate novel immunotherapies.
• Antiviral Agent Research: Investigated for its ability to induce interferon production and inhibit viral replication in preclinical studies.
• Pharmaceutical Intermediates: Acts as a key starting material or active component in the synthesis of advanced therapeutic nucleic acids.
• Cell Culture & In Vitro Diagnostics: Employed in assay systems to stimulate immune cells and study cytokine release profiles.

Basic Information

Product Name	Polycytidylic-Polyguanylic Acid Sodium
CAS No.	25280-45-9
Molecular Formula	(C9H11N3O7P • C10H12N5O7P)n • xNa
Molecular Weight	Variable (Polymer)
Synonyms	Poly(C)-Poly(G) Sodium Salt; Poly I:C; Polyinosinic:polycytidylic acid sodium salt (common mis-association); Polycytidylate-Polyguanylate Sodium; Sodium Polycytidylate-Polyguanylate; Poly r(C:rG); Poly(rC):Poly(rG); pIC; p(I:C); TLR3 Agonist; MDA5 Agonist
EINECS	Contact for details

Quality Control

Our Polycytidylic-Polyguanylic Acid Sodium is produced under stringent conditions to ensure batch-to-batch consistency and high biological activity. Quality is verified through a comprehensive suite of analytical techniques including HPLC for purity, spectrophotometry for concentration and base-pairing verification, and endotoxin testing. A Certificate of Analysis (COA) detailing identity, purity, biological activity (e.g., endotoxin levels, TLR activation assay), and physical specifications is provided with each batch to support your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This material is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake. For long-term storage, consider under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white fibrous solid or lyophilized powder
Identification (UV-Vis)	Spectrum characteristic of poly(C) and poly(G)
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95% (Polymer)
Absorbance Ratio (A250/A260)	0.40 - 0.60 (Indicative of double-stranded structure)
Molecular Size (SEC/GPC)	Specified range available (e.g., 1.0-2.5 kDa, 5.0-8.0 kDa)
Endotoxin	< 10 EU/mg (or lower upon request)
Biological Activity (Cell-based Assay)	Induces IFN-α/β in specified cell line at defined concentration
Water Content (KF)	< 5.0 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.