Description

Polyguanylic Acid Potassium Salt Lyophilized is a high-purity, synthetic polynucleotide derivative of guanosine monophosphate, widely utilized in biochemical and pharmaceutical research. Its primary value lies in its role as a critical reagent for studying RNA structure, function, and interactions, as well as in the development of nucleic acid-based therapeutics. This product is essential for researchers and manufacturers in the fields of molecular biology, virology, and advanced drug discovery, particularly for applications requiring a defined and stable polynucleotide backbone.

Application

• Biochemical Research: Used as a model homopolymer for studying RNA secondary structures, hybridization kinetics, and enzyme mechanisms (e.g., RNase activity).
• Pharmaceutical Development: Serves as a critical starting material or reference standard in the research and quality control of oligonucleotide-based drugs, including antisense oligonucleotides and aptamers.
• Diagnostic Assay Development: Employed in the design and calibration of diagnostic kits that detect or quantify specific RNA sequences.
• Vaccine Adjuvant Research: Investigated for its immunostimulatory properties as a potential component in novel vaccine formulations.
• Polymerase Studies: Acts as a template or primer in studies characterizing the activity and fidelity of viral and cellular RNA-dependent polymerases.
• Material Science: Used in the development of nucleic acid-based nanomaterials and biosensors due to its self-assembly properties.

Basic Information

Product Name	Polyguanylic Acid Potassium Salt Lyophilized
CAS No.	25191-14-4
Molecular Formula	(C10H12KN5O8P)n
Molecular Weight	(345.30)n g/mol (monomer)
Synonyms	Poly(G) Potassium Salt; Potassium Polyguanylate; Polyguanylate Potassium Salt; 5'-Guanylic Acid Homopolymer Potassium Salt; Poly(rG) Potassium Salt; Polyriboguanylic Acid Potassium Salt; PGR Potassium Salt; Polynosinic Acid Homopolymer Potassium Salt (related).
EINECS	Contact for details

Quality Control

Our Polyguanylic Acid Potassium Salt Lyophilized is manufactured under controlled conditions to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot undergoes rigorous analytical testing, including HPLC for purity assessment, spectrophotometry for concentration verification, and gel electrophoresis for chain length integrity. A comprehensive Certificate of Analysis (COA) detailing identity, purity, absorbance ratios (A260/A280), and endotoxin levels is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This material is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (UV-Vis)	Characteristic absorbance maximum at ~252 nm
Purity (HPLC)	≥ 95% (Poly(G) content)
A260/A280 Ratio	0.45 - 0.55
Potassium Content	7.0 - 9.0 %
Water Content (KF)	≤ 5.0 %
Endotoxin	< 10 EU/mg
Solubility	Soluble in water and buffer solutions

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.