Description

Polyinosinic Acid-Polycytidylic Acid CAS NO 24939-03-5 is a synthetic double-stranded RNA (dsRNA) polymer, widely recognized as a potent immunostimulant and interferon inducer. This compound is crucial for its ability to mimic viral genetic material, triggering robust innate immune responses in research and therapeutic development. It is an essential reagent for immunologists, virologists, and pharmaceutical developers working on vaccine adjuvants, antiviral therapies, and cancer immunotherapy. The product is supplied to meet the stringent requirements of advanced biomedical research and biopharmaceutical manufacturing.

Application

• Immunological Research: Used as a standard toll-like receptor 3 (TLR3) agonist to study innate immune signaling pathways and interferon production.
• Vaccine Adjuvant Development: Employed in preclinical studies to enhance the immunogenicity of vaccine candidates, particularly for viral and cancer vaccines.
• Antiviral Agent Screening: Serves as a positive control or challenge agent in assays designed to discover and evaluate new antiviral compounds.
• Cancer Immunotherapy Research: Investigated for its potential to stimulate anti-tumor immune responses and as a component of immunogenic cell death studies.
• Cell Culture & In Vitro Studies: Applied to stimulate immune cells like dendritic cells, macrophages, and peripheral blood mononuclear cells (PBMCs) in culture.
• Standard Reference Material: Used to calibrate assays and validate methods in laboratories focusing on dsRNA detection and immune activation.

Basic Information

Product Name	Polyinosinic Acid-Polycytidylic Acid
CAS No.	24939-03-5
Molecular Formula	(C10H13N4O7P · C9H14N3O7P)n
Molecular Weight	Variable (Polymer)
Synonyms	Poly(I:C); Polyinosinic-polycytidylic acid; Poly I:C; Poly I-poly C; PIC; Poly I · Poly C; dsRNA (synthetic); TLR3 Agonist; Hiltonol (brand name); Inosinic acid-cytidylic acid copolymer
EINECS	Contact for details

Quality Control

Our Polyinosinic Acid-Polycytidylic Acid is produced and tested under strict quality management systems to ensure batch-to-batch consistency and reliability for critical research applications. Each lot is characterized for identity, purity, and biological activity. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing specifications such as absorbance ratios (A260/A280), endotoxin levels, and functional activity in standardized bioassays. We support compliance with relevant guidelines for research-grade biomaterials.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, desiccate at -20°C. Aliquot to avoid repeated freeze-thaw cycles. Handle under controlled, dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white fibrous solid or lyophilized powder
Identification (UV-Vis)	Characteristic absorbance profile for dsRNA
Absorbance Ratio (A260/A280)	1.8 - 2.0
Purity (HPLC)	≥ 95% (dsRNA polymer)
Endotoxin	< 10 EU/mg
Biological Activity (Cell-based assay)	Induces IFN-α/β at defined concentrations
Solubility	Soluble in sterile, endotoxin-free water or buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.