Description

Polyadenylic-Polyuridylic Acid Sodium is a synthetic, double-stranded RNA (dsRNA) polymer composed of polyadenylic acid and polyuridylic acid strands complexed with sodium ions. This compound serves as a critical research tool and a potent immunostimulant, mimicking viral dsRNA to activate innate immune pathways. It is essential for researchers and manufacturers in the fields of immunology, virology, and vaccine development, where it is used to study interferon induction, antiviral responses, and as an adjuvant in experimental formulations.

Application

• Immunological Research: As a standard ligand for Toll-like receptor 3 (TLR3) and other pattern recognition receptors (PRRs) to study innate immune activation and interferon signaling pathways.
• Vaccine Adjuvant Development: Used in preclinical research to evaluate the efficacy of novel adjuvants that enhance immune response to antigens.
• Antiviral Studies: Employed to induce an antiviral state in cell cultures and animal models for screening antiviral compounds.
• Oncology Research: Investigated for its potential to stimulate immune responses against tumors in immunotherapy research.
• Biochemical Standard: Serves as a reference standard in assays measuring dsRNA binding or nuclease activity.
• Cell Signaling Studies: Used to activate protein kinase R (PKR) and other dsRNA-responsive enzymes to elucidate cellular stress response mechanisms.

Basic Information

Product Name	Polyadenylic-Polyuridylic Acid Sodium
CAS No.	24936-38-7
Molecular Formula	(C10H12N5O7P • C9H11N2O9P • Na)n
Molecular Weight	Variable polymer
Synonyms	Poly(A:U) Sodium Salt; Polyadenylic-Polyuridylic Acid Sodium Salt; Poly A:U; Polyadenylic Acid-Polyuridylic Acid Complex Sodium; Poly rA:rU Sodium Salt; dsRNA Poly(A-U); Sodium Polyadenylate-Polyuridylate; Poly A-Poly U Sodium
EINECS	Contact for details

Quality Control

Our Polyadenylic-Polyuridylic Acid Sodium is produced under controlled conditions to ensure batch-to-batch consistency for research applications. Each lot undergoes rigorous analytical testing. A comprehensive Certificate of Analysis (COA) is provided, detailing parameters such as identity, purity, and bioburden, ensuring it meets the stringent requirements for life science research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, desiccate. Aliquot to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White or off-white fibrous solid or lyophilized powder
Identification (UV-Vis)	Characteristic absorption spectrum for poly(A:U)
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95% (Poly(A:U) content)
pH (Solution)	6.0 - 8.0
Endotoxin	< 10 EU/mg
Solubility	Soluble in water and buffer solutions
Biological Activity	Induces interferon production in standardized cell-based assays

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.