Description

Probenecid Sodium is the sodium salt form of probenecid, a well-established uricosuric agent and organic anion transporter inhibitor. This compound is critical for pharmaceutical research and development, particularly in studies involving drug transport, renal excretion, and pharmacokinetics. It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and academic institutions engaged in drug discovery and metabolic studies.

Application

• Pharmaceutical Intermediate: Serves as a key starting material or active pharmaceutical ingredient (API) in the synthesis of uricosuric medications.
• Pharmacokinetic Research: Used extensively in preclinical and clinical studies to inhibit the renal tubular secretion of other drugs (e.g., penicillins, cephalosporins, antivirals) to prolong their plasma half-life.
• Transporter Inhibition Studies: A standard tool in vitro and in vivo to study organic anion transporters (OATs) and multidrug resistance-associated proteins (MRPs).
• Gout Treatment Research: Employed in developing and testing therapies for hyperuricemia and gout due to its uric acid excretion properties.
• Diagnostic Agent Development: Investigated for use in diagnostic procedures to assess kidney function and tubular secretion capacity.
• Biochemical Reagent: Used as a reference standard and reagent in analytical laboratories for method development and validation.

Basic Information

Product Name	Probenecid Sodium
CAS No.	23795-03-1
Molecular Formula	C13H18NNaO3S
Molecular Weight	291.34 g/mol
Synonyms	Benemid Sodium; Probenecid Sodium Salt; 4-[(Dipropylamino)sulfonyl]benzoic Acid Sodium Salt; Sodium Probenecid; p-(Dipropylsulfamoyl)benzoic Acid Sodium Salt; Probenecid Na; NSC 4911; Benzoic acid, 4-[(dipropylamino)sulfonyl]-, sodium salt (1:1)
EINECS	Contact for details

Quality Control

Our Probenecid Sodium is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including identification, purity assay, and impurity profiling, to ensure it meets stringent specifications for pharmaceutical research. Certificates of Analysis (COA) with detailed HPLC, NMR, and IR data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to prevent moisture absorption, which can affect stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤2.0%
Residue on Ignition	≤0.2%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%
Solubility	Freely soluble in water; soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.