Description

Droxidopa is a synthetic amino acid precursor used as a key pharmaceutical intermediate and active pharmaceutical ingredient (API). Its primary commercial value lies in its role as a prodrug for norepinephrine, making it critical for addressing specific neurological and cardiovascular conditions. This compound is essential for manufacturers in the pharmaceutical industry developing treatments for neurogenic orthostatic hypotension (nOH) and related autonomic disorders. Droxidopa CAS NO 23651-95-8 is supplied under stringent quality controls to meet the exacting standards of global API production.

Application

• Pharmaceutical API: Primary use as the active ingredient in prescription medications for neurogenic orthostatic hypotension (nOH).
• Neurological Research: Used as a biochemical tool in preclinical studies investigating catecholamine metabolism and autonomic nervous system function.
• Cardiovascular Drug Synthesis: Serves as a critical synthetic intermediate in the production of drugs targeting blood pressure regulation.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for HPLC, LC-MS, and pharmacopeial testing.
• Clinical Trial Material: Supplied as GMP-grade material for use in Phase I-III clinical trials for new therapeutic applications.
• Specialty Chemical Synthesis: Utilized as a chiral building block for the synthesis of more complex neuroactive compounds.

Basic Information

Product Name	Droxidopa
CAS No.	23651-95-8
Molecular Formula	C9H11NO5
Molecular Weight	213.19 g/mol
Synonyms	L-DOPS; L-Threo-DOPS; (-)-Three-DOPS; (2S,3R)-2-Amino-3-(3,4-dihydroxyphenyl)-3-hydroxypropanoic acid; SM-5688; Northera (brand name API); Droxidopa USP; L-Threo-dihydroxyphenylserine
EINECS	Contact for details

Quality Control

Our Droxidopa is manufactured and tested to meet stringent pharmaceutical-grade specifications. Quality assurance protocols are designed to ensure batch-to-batch consistency, identity, purity, and strength. We can supply material compliant with USP monograph standards for use as an API. A comprehensive Certificate of Analysis (COA) detailing purity, related substances, residual solvents, and other critical parameters is provided with each shipment to support your regulatory filings and quality systems.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Specific Rotation	-30.0° to -34.0° (c=1 in 1N HCl)
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.