Description

Adenosine-3',5'-Cyclic Phosphorothioate is a chemically modified, phosphorothioate analog of cyclic adenosine monophosphate (cAMP). This modification confers resistance to hydrolysis by phosphodiesterases, making it a potent and stable activator of cAMP-dependent protein kinase (PKA). It is an essential research-grade biochemical for investigating intracellular signaling pathways, particularly those mediated by cAMP. This high-purity compound is primarily utilized by pharmaceutical R&D, academic research institutions, and biotechnology companies focused on metabolic and cardiovascular research.

Application

• Biochemical Research: A stable, cell-permeable activator for studying cAMP/PKA signaling cascades in cell-based assays and in vitro enzymatic studies.
• Pharmaceutical Development: Used as a reference standard and a key tool compound in drug discovery programs targeting G-protein-coupled receptors (GPCRs) and intracellular kinases.
• Signal Transduction Studies: Critical for elucidating the role of cAMP in processes like gene expression, ion channel function, and metabolic regulation.
• Enzyme Kinetics: Serves as a substrate analog to investigate the specificity and inhibition of phosphodiesterases (PDEs).
• Cardiovascular & Metabolic Research: Applied in research models to understand cAMP's effects on heart muscle contraction, vascular tone, and insulin secretion.
• Neuroscience Research: Used to probe the role of PKA in neuronal plasticity, neurotransmitter release, and long-term potentiation (LTP).

Basic Information

Product Name	Adenosine-3',5'-Cyclic Phosphorothioate
CAS No.	23645-17-2
Molecular Formula	C10H12N5O5PS
Molecular Weight	345.27 g/mol
Synonyms	cAMPS; Adenosine 3',5'-cyclic monophosphorothioate; cAMP-S; Cyclic AMP phosphorothioate; Sp-cAMPS; Rp-cAMPS (stereoisomers); 8-(Thiophosphoryl)adenosine cyclic 3',5'-(hydrogen phosphate); Adenosine cyclic 3',5'-(hydrogen phosphorothioate)
EINECS	Contact for details

Quality Control

Every batch of Adenosine-3',5'-Cyclic Phosphorothioate is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, detailing key parameters such as assay, stereochemical purity, and impurity profiles. Our quality commitment aligns with the standards expected for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This compound is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Specific Rotation	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.