Description

Bacitracin F, 1-[n-[[2-(1-Amino-2-Methylbutyl)-4,5-Dihydro-4-Thiazolyl]Carbonyl]-L-Leucine]- is a specific, well-defined component of the Bacitracin complex, a group of polypeptide antibiotics. This compound is valued for its precise chemical structure, which is critical for research into the structure-activity relationships and biosynthesis of the Bacitracin family. It serves as an essential reference standard and building block for pharmaceutical R&D, analytical method development, and specialized microbiological studies. Industrial buyers in the pharmaceutical, biotechnology, and fine chemical synthesis sectors rely on this high-purity material for consistent, reproducible results.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the identification, assay, and impurity profiling of Bacitracin in pharmacopeial methods (USP/EP).
• Antibiotic Research: Serves as a key intermediate or standard in studies investigating the mechanism of action, resistance, and novel derivatives of polypeptide antibiotics.
• Analytical Method Development: Essential for developing and validating precise HPLC, LC-MS, or microbiological assays for Bacitracin complex analysis.
• Biochemical Synthesis: Employed as a defined substrate or intermediate in enzymatic studies and the synthesis of specialized peptide analogs.
• Quality Control Laboratories: Used by manufacturers and QC labs to ensure the consistency and composition of commercial Bacitracin products.
• Microbiological Studies: Applied in research to understand the specific activity spectrum of individual Bacitracin components against Gram-positive bacteria.

Basic Information

Product Name	Bacitracin F, 1-[n-[[2-(1-Amino-2-Methylbutyl)-4,5-Dihydro-4-Thiazolyl]Carbonyl]-L-Leucine]-
CAS No.	22601-59-8
Molecular Formula	C66H103N17O16S
Molecular Weight	1422.7 g/mol
Synonyms	Bacitracin F; Bacitracin Component F; 1-[N-[[2-(1-Amino-2-methylbutyl)-4,5-dihydro-4-thiazolyl]carbonyl]-L-leucine]bacitracin; Bacitracin A1; Bacitracin FA; (3S,6R,9S,12S,15R,18S,21S,24S,30S,33S)-30-[(2R)-2-Amino-3-methylbutanamido]-33-[(1R)-1-amino-2-methylbutyl]-6,9,18,21,24-pentaisobutyl-3,12,15-tris(1H-imidazol-5-ylmethyl)-1,4,7,10,13,16,19,22,25,28,31-undecaoxo-1-thia-4,7,10,13,16,19,22,25,28,31-decaazacyclotetratriacontane-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our Bacitracin F is produced and controlled under a strict quality management system. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, aligning with the standards expected for pharmaceutical reference materials. Certificates of Analysis (COA) are provided, detailing results from HPLC, MS, NMR, and other relevant pharmacopeial tests. We support compliance with cGMP and ISO 9001 standards for traceability and reliability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation from atmospheric moisture. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Heavy Metals	≤ 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.