Description

Methyl 2-Chloro-3-Nitro-5-(Trifluoromethyl)Benzoate is a high-value, multi-functional aromatic ester building block. This compound is critical for its role as a versatile intermediate in advanced organic synthesis, particularly in the development of complex molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those containing trifluoromethyl and nitro-substituted aromatic systems.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the chloronitrotoluene scaffold provides specific bioactivity.
• Material Science Research: Serves as a monomer or functionalizing agent in the development of specialty polymers and advanced organic materials.
• Dye & Pigment Intermediate: Utilized in the synthesis of complex organic dyes and pigments due to its nitro and ester functional groups.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) for creating biaryl structures.
• Chemical Research & Development: A valuable building block for medicinal chemistry and process chemistry in exploring new synthetic pathways.

Basic Information

Product Name	Methyl 2-Chloro-3-Nitro-5-(Trifluoromethyl)Benzoate
CAS No.	22235-23-0
Molecular Formula	C9H5ClF3NO4
Molecular Weight	283.59 g/mol
Synonyms	Benzoic acid, 2-chloro-3-nitro-5-(trifluoromethyl)-, methyl ester; Methyl 2-chloro-3-nitro-5-(trifluoromethyl)benzoate; 2-Chloro-3-nitro-5-(trifluoromethyl)benzoic acid methyl ester; Methyl 2-chloro-3-nitro-alpha,alpha,α-trifluoro-p-toluate; Methyl 2-chloro-3-nitro-5-trifluoromethylbenzoate; 22235-23-0; Methyl ester of 2-chloro-3-nitro-5-trifluoromethylbenzoic acid
EINECS	Contact for details

Quality Control

Our Methyl 2-Chloro-3-Nitro-5-(Trifluoromethyl)Benzoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and batch-to-batch consistency suitable for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive; prolonged exposure to light should be avoided to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.