Description

Olesoxime CAS NO 22033-87-0 is a synthetic, small-molecule compound belonging to the class of cholesterol-oxime derivatives. It is primarily recognized for its significant neuroprotective and neuroregenerative properties, making it a compound of high interest in advanced biomedical research and development. This product is essential for pharmaceutical companies, research institutions, and biotechnology firms focused on developing novel therapeutics for neurodegenerative diseases and nerve injury.

Application

• Neurodegenerative Disease Research: A key investigational compound for studying therapeutic pathways in conditions such as Amyotrophic Lateral Sclerosis (ALS), Parkinson's disease, and Alzheimer's disease.
• Spinal Cord Injury & Nerve Regeneration: Used in preclinical models to evaluate its efficacy in promoting axonal protection and functional recovery after neural trauma.
• Mitochondrial Function Modulator: Employed in research targeting mitochondrial permeability transition pore (mPTP) inhibition to prevent apoptosis in neuronal and other cell types.
• Pharmaceutical Intermediate: Serves as a critical intermediate or active pharmaceutical ingredient (API) in the synthesis of advanced neuroprotective drug candidates.
• Academic & Clinical Research: Supplied to universities and hospitals for fundamental studies on neurobiology, neuropharmacology, and the mechanisms of cell death.
• Biomarker & Assay Development: Utilized as a reference standard in the development and validation of analytical methods (e.g., HPLC, LC-MS) for pharmacokinetic and metabolic studies.

Basic Information

Product Name	Olesoxime
CAS No.	22033-87-0
Molecular Formula	C27H45NO2
Molecular Weight	415.66 g/mol
Synonyms	TRO19622; Cholest-4-en-3-one, oxime, (3E)-; (3E)-Cholest-4-en-3-one oxime; TRO-19622; Olesoxime (TRO19622); 4-Cholesten-3-one, oxime; EINECS 244-734-1
EINECS	244-734-1

Quality Control

Our Olesoxime is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development purposes. Each lot undergoes comprehensive analytical testing, including identification by spectroscopic methods (IR, NMR), purity assessment by HPLC, and control of related substances. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with our stringent in-house specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive (store away from light) and should be handled under inert atmosphere when appropriate to ensure long-term stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.