Description

4-Hydroxypenicillin V is a key semi-synthetic penicillin derivative and a vital intermediate in the synthesis of advanced β-lactam antibiotics. Its significance lies in providing a versatile chemical scaffold for developing new antimicrobial agents with potentially enhanced efficacy or altered resistance profiles. This compound is primarily needed by pharmaceutical R&D laboratories, fine chemical manufacturers, and companies specializing in the production of active pharmaceutical ingredients (APIs) for the global pharmaceutical market.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of novel penicillin and cephalosporin-based antibiotics.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies to develop new antimicrobial compounds.
• Fine Chemical Synthesis: Employed in multi-step organic syntheses to introduce the 4-hydroxypenicillanic acid moiety into more complex molecules.
• API Manufacturing: Acts as a building block in the controlled production of active pharmaceutical ingredients for clinical use.
• Biochemical Research: Utilized in studies investigating bacterial resistance mechanisms and the mode of action of β-lactam antibiotics.

Basic Information

Product Name	4-Hydroxypenicillin V
CAS No.	20880-67-5
Molecular Formula	C16H18N2O6S
Molecular Weight	366.39 g/mol
Synonyms	4-Hydroxyphenoxymethylpenicillin; (2S,5R,6R)-3,3-Dimethyl-7-oxo-6-[(4-hydroxyphenoxy)acetamido]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; 4-Hydroxy Penicillin V; Penicillin V, 4'-hydroxy-; 4-HP-V; 4-Hydroxyphenoxyacetamidopenicillanic acid
EINECS	Contact for details

Quality Control

Our 4-Hydroxypenicillin V is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with key parameters including assay, related substances, and residual solvents. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply for critical research and manufacturing processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.