Description

n-Acetyl-β-D-Glucosamine Phenylisothiocyanate is a specialized derivative of N-acetylglucosamine, functionalized with a phenylisothiocyanate group. This compound is a critical reagent for the selective labeling and sequencing of glycoproteins and oligosaccharides, enabling advanced research in glycobiology. It is essential for scientists and manufacturers in the pharmaceutical, biotechnology, and life science research sectors who require high-purity building blocks for carbohydrate analysis and synthesis.

Application

• Glycoprotein Sequencing: A key reagent for the Edman degradation of glycopeptides, facilitating the analysis of glycosylation sites and patterns.
• Oligosaccharide Labeling: Used to derivatize reducing ends of oligosaccharides for enhanced detection in chromatographic (HPLC, UPLC) and mass spectrometric analyses.
• Bioconjugation: Serves as a versatile intermediate for synthesizing carbohydrate-based probes, sensors, and targeted drug delivery systems.
• Enzymology Studies: Employed as a substrate or inhibitor in studies of glycosyltransferases, glycosidases, and other carbohydrate-active enzymes.
• Pharmaceutical Intermediate: Acts as a building block in the research and development of novel therapeutic agents targeting carbohydrate-mediated biological processes.
• Diagnostic Reagent Manufacturing: Utilized in the production of diagnostic kits and assays for detecting specific carbohydrate biomarkers.

Basic Information

Product Name	n-Acetyl-β-D-Glucosamine Phenylisothiocyanate
CAS No.	20581-43-5
Molecular Formula	C15H18N2O6S
Molecular Weight	354.38 g/mol
Synonyms	N-Acetyl-D-glucosamine phenylisothiocyanate; 2-Acetamido-2-deoxy-D-glucopyranose phenylisothiocyanate; PITC-GlcNAc; 1,3,4,6-Tetra-O-acetyl-2-deoxy-2-phthalimido-β-D-glucopyranose phenylisothiocyanate derivative; GlcNAc-PITC; NAG-PITC; Phenyl isothiocyanate derivative of N-acetylglucosamine
EINECS	Contact for details

Quality Control

Our n-Acetyl-β-D-Glucosamine Phenylisothiocyanate is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and specific tests for moisture content. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.