Description

Nicotine Hydrochloride is the water-soluble salt form of nicotine, offering enhanced stability and precise dosing for pharmaceutical and research applications. This high-purity compound is essential for formulating smoking cessation aids, such as gums and lozenges, and serves as a critical reference standard in analytical laboratories. It is primarily utilized by the pharmaceutical industry, agrochemical researchers, and manufacturers of nicotine replacement therapy (NRT) products who require a reliable and consistent active pharmaceutical ingredient (API).

Application

• Pharmaceutical API: Key active ingredient in nicotine replacement therapy (NRT) products including gums, lozenges, transdermal patches, and inhalers.
• Analytical Reference Standard: Certified reference material for quality control and analytical method development in pharmaceutical and toxicology laboratories.
• Biochemical Research: Used in neuroscience and pharmacology studies to investigate nicotinic acetylcholine receptors (nAChRs) and related neurological pathways.
• Agrochemical Intermediary: Serves as a precursor or intermediate in the synthesis of certain neonicotinoid insecticides and other specialty chemicals.
• Veterinary Medicine: Component in certain animal health products for parasite control.

Basic Information

Product Name	Nicotine Hydrochloride
CAS No.	2820-51-1
Molecular Formula	C₁₀H₁₅ClN₂
Molecular Weight	198.69 g/mol
Synonyms	(-)-Nicotine Hydrochloride; (S)-Nicotine Hydrochloride; Nicotine HCl; 3-[(2S)-1-Methylpyrrolidin-2-yl]pyridine hydrochloride; L-Nicotine Hydrochloride; Nicotine Monohydrochloride; Nicotine Chloride; Nicotine Hydrochloride Salt
EINECS	220-591-0

Quality Control

Our Nicotine Hydrochloride is manufactured under strict quality management systems. Each batch is tested to ensure it meets high-purity standards suitable for pharmaceutical and research use. A comprehensive Certificate of Analysis (COA) is provided, detailing parameters such as assay, optical rotation, related substances, and residual solvents. We can supply material compliant with in-house specifications and support customer-specific validation requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Assay (HPLC)	≥98.0% (anhydrous basis)
Specific Optical Rotation	-105° to -115° (c=2 in H₂O)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Related Substances (HPLC)	Total impurities ≤2.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.