Description

(6R)-6α-[(4-Aminophenyl)Acetylamino]Penicillanic Acid CAS NO 2510-42-1 is a key semi-synthetic penicillin derivative, serving as a crucial advanced intermediate in the synthesis of β-lactam antibiotics. Its primary value lies in providing the core chemical scaffold for developing potent, targeted antimicrobial agents. This high-purity intermediate is essential for pharmaceutical manufacturers and research institutions engaged in the development and production of novel penicillin-based drugs.

Application

• Pharmaceutical Intermediate: Primary use as a critical building block in the synthesis of semi-synthetic penicillin antibiotics, such as ampicillin and amoxicillin derivatives.
• Antibiotic Research & Development: Serves as a foundational compound in medicinal chemistry for creating new β-lactam structures with improved efficacy and resistance profiles.
• Active Pharmaceutical Ingredient (API) Manufacturing: Used in the controlled synthesis of final API batches under Good Manufacturing Practice (GMP) conditions.
• Biochemical Research: Employed in studies investigating the structure-activity relationship (SAR) of penicillin compounds and bacterial cell wall synthesis inhibition.
• Reference Standard: Utilized as a high-purity analytical standard for quality control and regulatory testing in pharmaceutical laboratories.

Basic Information

Product Name	(6R)-6α-[(4-Aminophenyl)Acetylamino]Penicillanic Acid
CAS No.	2510-42-1
Molecular Formula	C16H19N3O4S
Molecular Weight	349.41 g/mol
Synonyms	6-APA Derivative; 6-[(4-Aminophenyl)acetamido]penicillanic Acid; (6R)-6-[(4-Aminophenyl)acetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid; Ampicillin Intermediate; D-(-)-α-Aminobenzylpenicillinic Acid Precursor; 4-Amino-D-phenylglycyl-6-aminopenicillanic Acid; 6-[(Aminophenylacetyl)amino]penicillanic Acid
EINECS	Contact for details

Quality Control

Our (6R)-6α-[(4-Aminophenyl)Acetylamino]Penicillanic Acid is manufactured under strict quality systems to ensure it meets the exacting standards required for pharmaceutical synthesis. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Quality is assured through analytical methods including HPLC, IR, and NMR spectroscopy. While produced under conditions aligned with GMP principles for intermediates, specifications can be tailored to meet specific pharmacopeial requirements (e.g., USP, EP) upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.