Description

Cyclothiazide CAS NO 2259-96-3 is a potent thiazide-class diuretic and antihypertensive agent. This compound is valued for its specific pharmacological activity in research and development settings, particularly for studying renal electrolyte transport and cardiovascular mechanisms. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and manufacturers of fine chemicals and reference standards. Our supply ensures high purity and batch-to-batch consistency critical for sensitive experimental work.

Application

• Pharmaceutical Research & Development: As a reference standard and active pharmaceutical ingredient (API) intermediate in the study of diuretics and antihypertensive drugs.
• Biochemical Research: Investigation of renal tubular function, sodium-chloride symporter (NCC) inhibition, and electrolyte balance mechanisms.
• Pharmacology Studies: Used in preclinical models to evaluate diuretic efficacy, dose-response relationships, and cardiovascular effects.
• Analytical Chemistry: Serves as a high-purity calibration standard for HPLC, LC-MS, and other analytical methods in quality control laboratories.
• Fine Chemical Synthesis: A key building block or intermediate for the synthesis of more complex molecules in medicinal chemistry.
• Academic & Institutional Research: Fundamental research in universities and teaching hospitals focused on nephrology and hypertension.

Basic Information

Product Name	Cyclothiazide
CAS No.	2259-96-3
Molecular Formula	C₁₄H₁₆ClN₃O₄S₂
Molecular Weight	389.88 g/mol
Synonyms	Cyclothiazide; 6-Chloro-3,4-dihydro-3-(5-norbornen-2-yl)-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; Aquirel; Anhydron; Doburil; 6-Chloro-3-(2-norbornen-5-yl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; Cyclopenthiazide (related compound); Benzothiadiazine derivative
EINECS	218-861-8

Quality Control

Our Cyclothiazide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and potency meet stringent specifications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing results from HPLC, NMR, and other relevant pharmacopeial tests. Our quality commitment supports applications requiring research-grade and reference standard materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.