Description

5-(N,N-Dimethyl)-Amiloride (Hydrochloride) is a high-purity, small-molecule chemical compound primarily utilized as a selective inhibitor of the epithelial sodium channel (ENaC). This compound is of significant value in biochemical and pharmacological research for studying ion transport mechanisms and related physiological pathways. It is essential for researchers and developers in the pharmaceutical, life sciences, and academic sectors who require reliable, high-quality research chemicals for target validation and mechanistic studies.

Application

• Biochemical Research: Used as a potent and selective inhibitor of the epithelial sodium channel (ENaC) in in vitro studies.
• Pharmacological Studies: Employed in research to investigate sodium ion transport, fluid balance, and related cardiovascular or renal functions.
• Academic Research: A key tool compound for university and institutional labs focusing on membrane biology and ion channel physiology.
• Drug Discovery & Development: Serves as a reference standard or lead compound in the development of novel diuretics or treatments for hypertension and cystic fibrosis.
• Diagnostic Reagent Development: Potential use in the formulation of assay kits for screening ENaC activity or modulators.

Basic Information

Product Name	5-(N,N-Dimethyl)-Amiloride (Hydrochloride)
CAS No.	2235-97-4
Molecular Formula	C8H12ClN7O • HCl
Molecular Weight	302.15 g/mol
Synonyms	5-(N,N-Dimethyl)amiloride HCl; 5-(Dimethylamino)amiloride hydrochloride; 3,5-Diamino-6-chloro-N-(dimethylamino)pyrazinecarboxamide hydrochloride; Benzamil analog; ENaC Inhibitor V; DMA; Dimethylamiloride hydrochloride
EINECS	Contact for details

Quality Control

Our 5-(N,N-Dimethyl)-Amiloride (Hydrochloride) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with research-grade specifications and customer requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.