Description

Potassium Canrenoate is a steroidal compound and a potassium-sparing diuretic agent. It functions as a specific aldosterone antagonist, making it a critical intermediate in the synthesis of pharmaceutical active ingredients. This compound is essential for manufacturers in the pharmaceutical industry developing treatments for conditions like hypertension and congestive heart failure. Its reliable quality and consistent supply are paramount for ensuring the safety and efficacy of the final drug products.

Application

• Pharmaceutical Intermediate: Primary use as a key building block in the synthesis of Canrenone and Spironolactone, which are active pharmaceutical ingredients (APIs) for diuretic and antihypertensive medications.
• Aldosterone Antagonist Research: Serves as a reference standard and starting material in biochemical and pharmacological research focused on mineralocorticoid receptor activity.
• Cardiovascular Drug Development: Utilized in the R&D and production of drugs targeting heart failure, hypertension, and conditions involving fluid retention (edema).
• High-Purity Chemical Synthesis: Employed in fine chemical synthesis where high-purity, well-characterized steroid derivatives are required.
• Analytical Standard: Used as a certified reference material (CRM) in quality control laboratories for HPLC, LC-MS, or other analytical method development and validation.

Basic Information

Product Name	Potassium Canrenoate
CAS No.	2181-04-6
Molecular Formula	C22H27KO4
Molecular Weight	394.55 g/mol
Synonyms	Canrenoate Potassium; Potassium 3-(3-Oxo-17β-hydroxy-4,6-androstadien-17α-yl)propanoate; Aldadiene Potassium; SC-14266; (17α)-3-Oxo-4,6-pregnadiene-21-carboxylic acid, 17-hydroxy-, γ-lactone, potassium salt; 17-Hydroxy-3-oxo-17α-pregna-4,6-diene-21-carboxylic acid γ-lactone potassium salt; Canrenone potassium salt
EINECS	218-552-5

Quality Control

Our Potassium Canrenoate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for identity, purity, and impurity profiles, consistent with ICH guidelines. A Certificate of Analysis (COA) detailing results for assay, related substances, residual solvents, and other critical parameters is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 2.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any individual impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.