Description

3-(E)-(Trifluoromethyl)Cinnamic Acid is a high-purity fluorinated organic building block essential for advanced chemical synthesis. This compound is valued for its trifluoromethyl-substituted aromatic structure, which imparts unique electronic and steric properties to target molecules. It is primarily utilized by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and materials science sectors for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting inflammation, oncology, and central nervous system disorders.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and plant growth regulators where the trifluoromethyl group enhances biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs), improving performance and durability.
• Polymer & Specialty Chemicals: Incorporated into polymer backbones and specialty chemicals to modify physical properties such as thermal stability, chemical resistance, and surface characteristics.
• Chemical Research & Development: A versatile building block in academic and industrial R&D for exploring new reactions, catalysis, and the synthesis of complex fluorinated molecules.

Basic Information

Product Name	3-(E)-(Trifluoromethyl)Cinnamic Acid
CAS No.	2143-93-3
Molecular Formula	C10H7F3O2
Molecular Weight	216.16 g/mol
Synonyms	(E)-3-[3-(Trifluoromethyl)phenyl]acrylic acid; 3-(Trifluoromethyl)cinnamic acid; trans-3-(3-Trifluoromethylphenyl)propenoic acid; α-(3-Trifluoromethylphenyl)acrylic acid; 3-(α,α,α-Trifluoro-m-tolyl)acrylic acid; (E)-3-(3-(Trifluoromethyl)phenyl)-2-propenoic acid; m-Trifluoromethylcinnamic acid
EINECS	218-392-9

Quality Control

Our 3-(E)-(Trifluoromethyl)Cinnamic Acid is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring high-purity intermediates for GMP and research purposes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	142 - 146 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Isomeric Purity (E/Z ratio)	≥ 99:1 (E/Z)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.