Description

Amiloride Hydrochloride Hydrate is a high-purity pharmaceutical intermediate and research chemical. This compound is critical for the development and production of diuretic medications, specifically potassium-sparing agents. It is primarily utilized by pharmaceutical manufacturers, research institutions, and fine chemical suppliers engaged in cardiovascular and renal therapy development.

Application

• Pharmaceutical Active Ingredient (API): Key intermediate in the synthesis of Amiloride HCl, a potassium-sparing diuretic used to treat hypertension and congestive heart failure.
• Biochemical Research: Used as a selective inhibitor of epithelial sodium channels (ENaC) in physiological and pharmacological studies.
• Reference Standard: Serves as a certified reference material (CRM) for quality control and analytical method development in pharmaceutical laboratories.
• Preclinical Development: Employed in formulation studies and pharmacokinetic research for new drug entities targeting ion transport mechanisms.
• Fine Chemical Synthesis: Building block for the preparation of more complex molecules and analogs in medicinal chemistry.

Basic Information

Product Name	Amiloride Hydrochloride Hydrate
CAS No.	2106-88-8
Molecular Formula	C6H8ClN7O • HCl • xH2O
Molecular Weight	302.12 (Anhydrous Amiloride HCl)
Synonyms	Amiloride HCl Hydrate; 3,5-Diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamide hydrochloride hydrate; N-Amidino-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride hydrate; MK-870 hydrochloride hydrate; Midamor hydrochloride hydrate; Guanamprazine hydrochloride hydrate
EINECS	218-250-3

Quality Control

Our Amiloride Hydrochloride Hydrate is manufactured under strict quality management systems. We offer material compliant with pharmaceutical grade standards, suitable for use as a reference standard or API intermediate. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. Specifications can be aligned with USP, EP, or in-house pharmacopeial standards upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	Yellow to pale yellow crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0% (on anhydrous basis)
Water Content (KF)	≤6.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%
Single Maximum Unknown Impurity	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.