Description

5-Diethylamiloride is a specialized organic compound belonging to the amiloride analog family, valued for its role as a potent and selective research chemical. This compound is critical for biochemical and pharmacological studies, particularly in the investigation of ion channel function and cellular transport mechanisms. It is primarily utilized by research institutions, pharmaceutical R&D departments, and advanced chemical synthesis laboratories focused on developing novel therapeutic agents.

Application

• Biochemical Research: Used as a high-affinity ligand in studies of sodium ion channel (ENaC) inhibition and related transport pathways.
• Pharmacological Development: Serves as a key intermediate or reference standard in the discovery and development of new diuretic or cardioprotective agents.
• Mechanistic Studies: Employed in cellular and molecular biology to elucidate the mechanisms of action of epithelial sodium channel blockers.
• Reference Standard: Provides a certified standard for analytical method development and validation in quality control laboratories.
• Chemical Synthesis: Acts as a sophisticated building block for the synthesis of more complex amiloride derivatives with tailored biological activity.

Basic Information

Product Name	5-Diethylamiloride
CAS No.	2086-31-9
Molecular Formula	C10H14ClN7O
Molecular Weight	283.72 g/mol
Synonyms	5-(N,N-Diethyl)amiloride; 3,5-Diamino-6-chloro-N-(diethylamino)pyrazinecarboxamide; Benzamil analog; 5-DEA; Amiloride diethyl analog; 6-Chloro-3,5-diamino-N-(diethylamino)pyrazine-2-carboxamide; 5-(N,N-Diethylamino)amiloride
EINECS	Contact for details

Quality Control

Our 5-Diethylamiloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.