Description

Rac-(1R,2R)-2-(2,3-Difluorophenyl)Cyclopropane-1-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate featuring a cyclopropane ring substituted with a difluorophenyl moiety. This compound is valued for its role as a critical chiral building block in the synthesis of complex bioactive molecules, particularly in medicinal chemistry. It is primarily sought by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs), especially within therapeutic areas targeting the central nervous system and metabolic diseases.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel Active Pharmaceutical Ingredients (APIs).
• Medicinal Chemistry Research: Used as a building block for constructing complex molecular scaffolds in drug discovery programs.
• Protease Inhibitor Synthesis: Serves as a precursor in the synthesis of inhibitors targeting specific enzymes.
• Agrochemical Development: Potential intermediate for creating advanced crop protection agents with specific activity.
• Ligand Synthesis for Catalysis: Can be utilized to develop chiral ligands for asymmetric synthesis applications.
• Reference Standard: Serves as an analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Item	Details
Product Name	Rac-(1R,2R)-2-(2,3-Difluorophenyl)Cyclopropane-1-Carboxylic Acid
CAS No.	1955548-02-3
Molecular Formula	C10H8F2O2
Molecular Weight	198.17 g/mol
Synonyms	(1R,2R)-rel-2-(2,3-Difluorophenyl)cyclopropanecarboxylic Acid; (±)-(1R,2R)-2-(2,3-Difluorophenyl)cyclopropanecarboxylic Acid; rac-(1R,2R)-2-(2,3-Difluorophenyl)cyclopropanecarboxylic Acid; 2-(2,3-Difluorophenyl)cyclopropane-1-carboxylic Acid (racemic trans isomer); trans-2-(2,3-Difluorophenyl)cyclopropanecarboxylic Acid; Cyclopropanecarboxylic acid, 2-(2,3-difluorophenyl)-, (1R,2R)-rel-
EINECS	Contact for details

Quality Control

Our Rac-(1R,2R)-2-(2,3-Difluorophenyl)Cyclopropane-1-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. Keep away from incompatible materials such as strong bases and fluorides.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de (diastereomeric excess)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.