Description

Carbidopa 4'-Phosphate is a key phosphorylated derivative of Carbidopa, a well-known aromatic amino acid decarboxylase inhibitor. This compound is of significant interest in advanced pharmaceutical research and development, particularly for creating prodrugs with enhanced bioavailability and targeted delivery profiles. It serves as a critical synthetic intermediate and reference standard for researchers and manufacturers in the pharmaceutical and fine chemical sectors.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of novel prodrugs and active pharmaceutical ingredients (APIs), particularly for neurological and metabolic disorders.
• Reference Standard: Used for analytical method development, validation, and quality control (QC) testing in pharmaceutical laboratories to ensure product purity and consistency.
• Biochemical Research: Employed in enzymatic and metabolic pathway studies to investigate the role of decarboxylase inhibition and phosphate-mediated transport mechanisms.
• Prodrug Development: The phosphate moiety is leveraged to improve the water solubility and pharmacokinetic properties of drug candidates, facilitating better formulation and delivery.

Basic Information

Product Name	Carbidopa 4'-Phosphate
CAS No.	1907685-81-7
Molecular Formula	C10H14N2O6P
Molecular Weight	289.20 g/mol
Synonyms	(S)-3-(3,4-Dihydroxybenzyl)-2-hydrazino-2-methylpropanoic acid 4'-(dihydrogen phosphate); L-α-Hydrazino-3,4-dihydroxy-α-methylbenzenepropanoic acid 4'-phosphate; Carbidopa phosphate ester; 4'-Phosphonoxycarbidopa; (2S)-3-(3,4-Dihydroxyphenyl)-2-hydrozinyl-2-methylpropanoic acid 4'-(dihydrogen phosphate)
EINECS	Contact for details

Quality Control

Our Carbidopa 4'-Phosphate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent control of residual solvents and impurities. Certificates of Analysis (COA) with detailed chromatographic data are provided to ensure traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.