Description

2,5-Difluoro-4-formylbenzoic acid is a high-value, multi-functional aromatic building block containing both a formyl and a carboxylic acid group, strategically substituted with fluorine atoms. This unique structure makes it a critical intermediate for synthesizing advanced materials and active pharmaceutical ingredients (APIs), where fluorine substitution is used to modulate potency, metabolic stability, and bioavailability. It is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate difluorinated benzoic acid motifs into novel compounds.

Application

• Pharmaceutical Intermediate: Key synthon for the development of novel drug candidates, particularly in kinase inhibitors and other small molecule therapeutics where the difluoro-substituted benzoic acid scaffold is valuable.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and fungicides, leveraging the fluorine atoms to enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized chelating ligands and organocatalysts used in asymmetric synthesis and metal-organic frameworks (MOFs).
• Polymer and Material Science: A monomer or cross-linking agent for synthesizing high-performance polymers, liquid crystals, and organic electronic materials.
• Fluorescent Probe and Dye Chemistry: The formyl group allows for condensation reactions to create complex fluorophores and sensing molecules for analytical and diagnostic applications.
• Custom Synthesis and Contract Manufacturing: A pivotal starting material for custom chemical synthesis services catering to R&D and pilot-scale production needs.

Basic Information

Product Name	2,5-Difluoro-4-formylbenzoic Acid
CAS No.	1890953-67-9
Molecular Formula	C8H4F2O3
Molecular Weight	186.11 g/mol
Synonyms	4-Formyl-2,5-difluorobenzoic Acid; 2,5-Difluoro-4-carboxybenzaldehyde; Benzoic acid, 4-formyl-2,5-difluoro-; 1890953-67-9; 2,5-Difluoroterephthalaldehyde-4-carboxylic Acid
EINECS	Contact for details

Quality Control

Every batch of 2,5-Difluoro-4-formylbenzoic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive synthetic applications. A detailed Certificate of Analysis (COA), including results from HPLC, NMR, and MS, is supplied with each shipment to guarantee identity, purity, and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids, bases, and oxidizing agents. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.