Description

Benzoic Acid, 4-(2,2-Difluorocyclopropyl)- is a high-purity, fluorinated benzoic acid derivative characterized by its unique difluorocyclopropyl substituent, offering a valuable combination of aromatic stability and fluorine-induced electronic effects. This compound serves as a critical advanced pharmaceutical intermediate and a versatile building block for the synthesis of complex molecules in medicinal chemistry. It is primarily utilized by R&D laboratories and production facilities in the pharmaceutical, agrochemical, and specialty chemical industries to develop novel active ingredients with enhanced properties.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates targeting CNS disorders, metabolic diseases, and oncology.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, where the difluorocyclopropyl group can improve biological activity and environmental stability.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of monomers for advanced polymers, liquid crystals, and organic electronic materials.
• Fluorine Chemistry Studies: Acts as a model compound in academic and industrial research to study the influence of gem-difluoro and strained cyclopropyl motifs on molecular reactivity and conformation.

Basic Information

Product Name	Benzoic Acid, 4-(2,2-Difluorocyclopropyl)-
CAS No.	1889432-53-4
Molecular Formula	C10H8F2O2
Molecular Weight	198.17 g/mol
Synonyms	4-(2,2-Difluorocyclopropyl)benzoic Acid; 2,2-Difluoro-1-(4-carboxyphenyl)cyclopropane; p-(2,2-Difluorocyclopropyl)benzoic Acid; Benzoic acid, 4-(2,2-difluorocyclopropyl)-; 1889432-53-4; 4-(2,2-Difluorocyclopropyl)benzoate (acid form)
EINECS	Contact for details

Quality Control

Our Benzoic Acid, 4-(2,2-Difluorocyclopropyl)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, GC for residual solvents, and NMR/IR for structural confirmation, to ensure it meets the high standards required for research and commercial synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment. We support cGMP compliance for pharmaceutical applications and can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases, strong oxidizing agents, and sources of ignition. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5% w/w
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.