Description

2-(4-Chloro-3-Fluorophenyl)-2,2-Difluoroacetic Acid is a high-purity fluorinated aromatic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where its unique difluoroacetic acid moiety and halogenated phenyl ring enable precise modulation of biological activity and physicochemical properties. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate sophisticated fluorinated motifs into their target molecules.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors, anti-inflammatory agents, and CNS-active compounds.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides, fungicides, and insecticides, where the fluorine atoms enhance metabolic stability and bioavailability.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the development of fluorinated polymers, liquid crystals, and organic electronic materials to alter dielectric properties and environmental stability.
• Custom Synthesis & Contract Manufacturing: Supplied to CROs and CDMOs for client-specific projects requiring bespoke fluorinated chemical entities.

Basic Information

Product Name	2-(4-Chloro-3-Fluorophenyl)-2,2-Difluoroacetic Acid
CAS No.	1823840-58-9
Molecular Formula	C8H4ClF3O2
Molecular Weight	224.56 g/mol
Synonyms	2,2-Difluoro-2-(4-chloro-3-fluorophenyl)acetic Acid; (4-Chloro-3-fluorophenyl)difluoroacetic Acid; α,α-Difluoro-4-chloro-3-fluorophenylacetic Acid; 2-(4-Chloro-3-fluorophenyl)-2,2-difluoroethanoic Acid; 4-Chloro-3-fluorophenyl-difluoro-acetic acid; 1823840-58-9; Difluoro(4-chloro-3-fluorophenyl)acetic Acid
EINECS	Contact for details

Quality Control

Our 2-(4-Chloro-3-Fluorophenyl)-2,2-Difluoroacetic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports compliance with cGMP guidelines for advanced pharmaceutical intermediates, ensuring reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and potential degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.