Description

Ald-Ph-Peg3-Azide is a heterobifunctional polyethylene glycol (PEG) linker featuring an aldehyde group and a terminal azide, designed for advanced bioconjugation and click chemistry applications. This compound is essential for creating stable, site-specific linkages between biomolecules, polymers, and surfaces under mild reaction conditions. It is a critical reagent for researchers and manufacturers in pharmaceutical development, proteomics, and materials science, enabling the precise construction of drug conjugates, diagnostic probes, and functionalized nanomaterials.

Application

• Bioconjugation and Antibody-Drug Conjugate (ADC) Development: Site-specific coupling of drugs, toxins, or fluorophores to antibodies or proteins via the aldehyde group, followed by azide-alkyne cycloaddition for modular assembly.
• PEGylation and Linker Chemistry: Serving as a functionalized PEG spacer to improve the solubility, stability, and pharmacokinetic profiles of therapeutic peptides and small molecules.
• Surface Functionalization and Material Science: Immobilizing biomolecules onto sensor chips, nanoparticles, or polymeric matrices for biosensing, diagnostic assays, and tissue engineering scaffolds.
• Click Chemistry Reagent: The terminal azide group enables efficient, copper-catalyzed or strain-promoted azide-alkyne cycloaddition (CuAAC/SPAAC) with alkyne-modified compounds.
• Crosslinking Agent: Creating covalent networks between aldehyde-reactive amines (e.g., lysine residues) and other azide-functionalized components in hydrogel formation or polymer crosslinking.
• Proteomics and Biomarker Discovery: Labeling and enrichment of glycoproteins or other aldehyde-containing biomolecules for mass spectrometry analysis.

Basic Information

Item	Details
Product Name	Ald-Ph-Peg3-Azide
CAS No.	1807540-88-0
Molecular Formula	C19H27N3O6
Molecular Weight	393.44 g/mol
Synonyms	4-Formylbenzyl-PEG3-azide; 4-Formylbenzyl-PEG3-N3; Aldehyde-PEG3-Azide; Azido-PEG3-CH2-Ph-CHO; 1-Azido-3,6,9-trioxa-12-(4-formylbenzyl)-12-azadodecane; (Azido-PEG3)-benzaldehyde; Benzaldehyde-PEG3-azide; 4-(Azido-PEG3-methyl)benzaldehyde
EINECS	Contact for details

Quality Control

Our Ald-Ph-Peg3-Azide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry, to ensure it meets the high standards required for research and bioconjugation. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to guarantee traceability, consistency, and compliance with customer requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This compound is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption. For long-term storage, keep under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (NMR)	Complies with structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.