Description

4-Bromo-2-Fluoro-5-Hydroxy-Benzoic Acid Methyl Ester is a high-purity, multi-functional aromatic building block essential for advanced organic synthesis. This compound is valued for its unique halogenated and esterified structure, which provides versatile reactivity for constructing complex molecular architectures. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and material science.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in the synthesis of molecules with bromine and fluorine substituents for enhanced bioactivity and metabolic stability.
• Agrochemical Research: Used in the discovery and synthesis of novel herbicides, fungicides, and pesticides, where the halogen atoms can be crucial for target binding and environmental persistence.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing advanced organic electronic materials, where the ester and hydroxy groups allow for further functionalization.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Stille) to form biaryl structures.
• Fluorine Chemistry Studies: Utilized as a model compound in research exploring the effects of fluorine substitution on chemical reactivity and physical properties.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring specific halogenated benzoic acid derivatives.

Basic Information

Item	Detail
Product Name	4-Bromo-2-Fluoro-5-Hydroxy-Benzoic Acid Methyl Ester
CAS No.	1807144-89-3
Molecular Formula	C8H6BrFO3
Molecular Weight	249.04 g/mol
Synonyms	Methyl 4-Bromo-2-fluoro-5-hydroxybenzoate; 5-Hydroxy-4-bromo-2-fluorobenzoic Acid Methyl Ester; Benzoic acid, 4-bromo-2-fluoro-5-hydroxy-, methyl ester; 4-Bromo-2-fluoro-5-hydroxybenzoic acid methyl ester; Methyl 4-bromo-2-fluoro-5-hydroxybenzoate; 1807144-89-3; 4-Bromo-2-fluoro-5-hydroxy methyl benzoate
EINECS	Contact for details

Quality Control

Every batch of 4-Bromo-2-Fluoro-5-Hydroxy-Benzoic Acid Methyl Ester is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the precise requirements of your research or production process. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (HPLC, Area%)	≥98.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.