Description

Methyl 3,5-Difluoro-4-Methylbenzoate is a high-purity fluorinated aromatic ester building block essential for advanced organic synthesis. Its value lies in the strategic placement of fluorine atoms and the methyl ester group, which are critical for modulating the electronic properties, lipophilicity, and metabolic stability of target molecules. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and central nervous system (CNS) targeted drugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and fungicides, where the difluoro motif enhances biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated aromatic cores in electronic materials, improving charge transport and thermal stability.
• Functional Polymer Monomer: Incorporated into specialty polymers to impart unique chemical resistance, low surface energy, and optical properties.
• Cross-Coupling Reactions: The methyl ester group facilitates further transformations via hydrolysis to the carboxylic acid or transesterification, common in Suzuki and other palladium-catalyzed couplings.
• Chemical Research & Development: A versatile building block in academic and industrial labs for exploring new fluorination strategies and structure-activity relationships (SAR).

Basic Information

Product Name	Methyl 3,5-Difluoro-4-Methylbenzoate
CAS No.	1806321-10-7
Molecular Formula	C9H8F2O2
Molecular Weight	186.16 g/mol
Synonyms	3,5-Difluoro-4-methylbenzoic acid methyl ester; Methyl 3,5-difluoro-p-toluate; 4-Methyl-3,5-difluorobenzoic acid methyl ester; Benzoic acid, 3,5-difluoro-4-methyl-, methyl ester; Methyl 4-methyl-3,5-difluorobenzoate
EINECS	Contact for details

Quality Control

Our Methyl 3,5-Difluoro-4-Methylbenzoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided to guarantee traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and oxidizing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.