Description

Methyl 2,4-Difluoro-5-Methoxybenzoate is a high-purity fluorinated aromatic ester, serving as a critical advanced intermediate in modern organic synthesis. Its value lies in the strategic placement of fluorine and methoxy substituents, which are essential for modulating the electronic and steric properties of target molecules. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the difluoro-methoxy benzoate core contributes to enhanced biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated aromatic cores used in electronic materials, contributing to improved charge transport and thermal stability in display technologies.
• Organic Synthesis Reagent: Employed in cross-coupling reactions (e.g., Suzuki, Stille) and nucleophilic aromatic substitution reactions to introduce complex, multi-substituted benzoate motifs.
• Chemical Research & Development: A valuable scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis due to its versatile chemical handle.

Basic Information

Product Name	Methyl 2,4-Difluoro-5-Methoxybenzoate
CAS No.	1804416-21-4
Molecular Formula	C9H8F2O3
Molecular Weight	202.16 g/mol
Synonyms	2,4-Difluoro-5-methoxybenzoic acid methyl ester; Methyl 2,4-difluoro-5-methoxybenzoate; Benzoic acid, 2,4-difluoro-5-methoxy-, methyl ester; 5-Methoxy-2,4-difluorobenzoic acid methyl ester; Methyl 5-methoxy-2,4-difluorobenzoate; CAS 1804416-21-4
EINECS	Contact for details

Quality Control

Our Methyl 2,4-Difluoro-5-Methoxybenzoate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We support cGMP compliance for pharmaceutical applications and can tailor purity grades to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0% (Standard Grade)
Purity (HPLC)	≥99.0% (High Purity Grade)
Melting Point	Contact for details
Heavy Metals	<10 ppm
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.