Description

Lrrk2 Inhibitor 1 CAS NO 1802525-61-6 is a potent and selective small molecule inhibitor of the Leucine-rich repeat kinase 2 (LRRK2), a key therapeutic target in Parkinson's disease research. This high-purity compound is essential for preclinical studies investigating LRRK2's role in neuroinflammation, autophagy, and α-synuclein pathology. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and CROs focused on developing novel treatments for neurodegenerative disorders.

Application

• Parkinson's Disease Research: A critical tool compound for in vitro and in vivo studies to elucidate LRRK2 kinase function and validate its role in disease pathways.
• Drug Discovery & Development: Used as a reference standard and pharmacological probe in high-throughput screening (HTS) and lead optimization campaigns for LRRK2-targeted therapies.
• Mechanistic Biology Studies: Enables investigation of LRRK2-mediated signaling cascades, including Rab GTPase phosphorylation, lysosomal function, and mitochondrial dynamics.
• Preclinical Model Validation: Employed in animal models of Parkinson's disease to assess efficacy, pharmacokinetics, and biomarker modulation of LRRK2 inhibition.
• Biomarker Development: Supports research into identifying and quantifying phosphorylated Rab proteins as potential pharmacodynamic biomarkers for LRRK2 activity.

Basic Information

Product Name	Lrrk2 Inhibitor 1
CAS No.	1802525-61-6
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	LRRK2-IN-1; LRRK2 Inhibitor 1; 1802525-61-6; LRRK2 kinase inhibitor; Leucine-rich repeat kinase 2 inhibitor 1; (Chemical name based on structure - Contact for details)
EINECS	Contact for details

Quality Control

Our Lrrk2 Inhibitor 1 is manufactured under strict quality systems to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot undergoes comprehensive analytical characterization, including purity verification by HPLC and identity confirmation. A detailed Certificate of Analysis (COA) containing lot-specific data is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccated conditions. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and potency. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.