Description

6-Chloro-2,4-Difluoro-3-Methylbenzoic Acid is a high-purity, multi-functional benzoic acid derivative distinguished by its unique halogen-substituted aromatic structure. This compound serves as a critical advanced pharmaceutical intermediate and key building block in the synthesis of complex active molecules. It is primarily utilized by R&D and production teams in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific steric and electronic properties into their target compounds.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates targeting CNS disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides, where the difluoro and chloro substituents contribute to biological activity and metabolic stability.
• Ligand & Catalyst Precursor: Serves as a starting material for synthesizing specialized ligands used in transition metal catalysis and organic synthesis.
• Material Science Research: Employed in the development of specialty polymers, liquid crystals, and organic electronic materials due to its aromatic backbone and halogen functionalities.
• Custom Synthesis & Contract Manufacturing: An essential building block for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	6-Chloro-2,4-Difluoro-3-Methylbenzoic Acid
CAS No.	1706446-43-6
Molecular Formula	C8H5ClF2O2
Molecular Weight	206.57 g/mol
Synonyms	3-Methyl-6-chloro-2,4-difluorobenzoic Acid; 2,4-Difluoro-6-chloro-3-methylbenzoic Acid; 6-Chloro-2,4-difluoro-m-toluic Acid; Benzoic acid, 6-chloro-2,4-difluoro-3-methyl-; 1706446-43-6; 6-Chloro-2,4-difluoro-3-methyl-benzoic acid
EINECS	Contact for details

Quality Control

Our 6-Chloro-2,4-Difluoro-3-Methylbenzoic Acid is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure high chemical purity and structural identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply and batch-to-batch consistency for your critical R&D and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids, bases, and oxidizing agents. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.