Description

4-Methyl-2,5-Bis(trifluoromethyl)benzoic Acid is a high-value, multi-fluorinated benzoic acid derivative characterized by its unique steric and electronic properties imparted by the trifluoromethyl groups. This compound serves as a critical advanced pharmaceutical intermediate (API) and a versatile building block in the synthesis of complex organic molecules. It is primarily utilized by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty materials sectors for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for molecules requiring fluorinated aromatic systems to modulate bioavailability, metabolic stability, and lipophilicity.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides where the introduction of fluorine atoms enhances biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Acts as a precursor for fluorinated ligands and core structures in electronic display materials, contributing to improved dielectric anisotropy and thermal stability.
• Polymer Modification: Employed to introduce fluorine-containing side chains into polymers, enhancing properties such as chemical resistance, thermal stability, and surface characteristics.
• Organic Synthesis Building Block: Utilized in cross-coupling reactions, esterifications, and amide couplings to construct complex, fluorinated aromatic compounds for various R&D applications.
• Catalyst & Ligand Development: Serves as a starting material for synthesizing novel fluorinated ligands used in asymmetric catalysis and transition metal complexes.

Basic Information

Item	Details
Product Name	4-Methyl-2,5-Bis(trifluoromethyl)benzoic Acid
CAS No.	1706436-17-0
Molecular Formula	C11H6F6O2
Molecular Weight	284.16 g/mol
Synonyms	2,5-Bis(trifluoromethyl)-4-methylbenzoic acid; 4-Methyl-2,5-di(trifluoromethyl)benzoic acid; Benzoic acid, 4-methyl-2,5-bis(trifluoromethyl)-; α,α,α,α',α',α'-Hexafluoro-4-methyl-1,3-benzenediacetic acid (cyclic form); 4-Methyl-α,α,α,α',α',α'-hexafluoroversatic acid
EINECS	Contact for details

Quality Control

Our production of 4-Methyl-2,5-Bis(trifluoromethyl)benzoic Acid adheres to stringent in-process controls and final release testing protocols. We ensure high batch-to-batch consistency and purity suitable for demanding synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment. Our quality system is designed to support cGMP requirements for advanced intermediate manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases, oxidizing agents, and sources of ignition. Due to its nature as a strong acid/organic solvent, handle with appropriate personal protective equipment in a fume hood.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.