Description

6-Amino-3-Bromo-2-Fluoro-Benzoic Acid Methyl Ester is a high-purity, multi-functional aromatic building block essential for advanced organic synthesis. Its unique combination of amino, bromo, and fluoro substituents on the benzoate core makes it a versatile intermediate for constructing complex molecular architectures. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring halogenated and fluorinated aromatic systems.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides where the fluorine and bromine atoms enhance biological activity and environmental stability.
• Material Science Research: Serves as a monomer or functionalizing agent in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Biology & Proteomics: Employed as a derivatization agent or a building block for fluorescent probes and molecular tags due to its reactive amino and halogen groups.
• Cross-Coupling Reactions: The bromo substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) to form complex biaryl structures.
• Library Synthesis for Drug Discovery: A valuable scaffold in combinatorial chemistry and high-throughput screening for generating diverse compound libraries.

Basic Information

Product Name	6-Amino-3-Bromo-2-Fluoro-Benzoic Acid Methyl Ester
CAS No.	1637774-20-9
Molecular Formula	C8H7BrFNO2
Molecular Weight	248.05 g/mol
Synonyms	Methyl 6-Amino-3-Bromo-2-Fluorobenzoate; 2-Fluoro-6-Amino-3-Bromobenzoic Acid Methyl Ester; Benzoic acid, 6-amino-3-bromo-2-fluoro-, methyl ester; 3-Bromo-2-fluoro-6-aminobenzoic acid methyl ester; Methyl 3-bromo-2-fluoro-6-aminobenzoate
EINECS	Contact for details

Quality Control

Our 6-Amino-3-Bromo-2-Fluoro-Benzoic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.