Description

Methyl3-Bromo-6-Chloro-2-Fluorobenzoate is a high-purity fluorinated aromatic ester building block, essential for advanced organic synthesis. This compound is valued for its precise molecular architecture, enabling the introduction of multiple halogen substituents in a controlled spatial arrangement. It is primarily utilized by pharmaceutical and agrochemical R&D teams for the development of novel active ingredients, including kinase inhibitors and crop protection agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly kinase inhibitors and other small molecule therapeutics.
• Agrochemical Research: Used in the development of next-generation herbicides, fungicides, and insecticides requiring specific halogenated benzoate motifs.
• Material Science: Serves as a monomer or functionalization agent for creating specialty polymers with unique electronic or surface properties.
• Ligand Synthesis: Employed in the preparation of sophisticated ligands for catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Utilized to create fluorinated and halogenated probes for studying enzyme mechanisms and protein interactions.
• Custom Synthesis: A versatile starting material for contract research organizations (CROs) and fine chemical manufacturers performing bespoke synthesis.

Basic Information

Product Name	Methyl3-Bromo-6-Chloro-2-Fluorobenzoate
CAS No.	1543224-54-9
Molecular Formula	C8H5BrClFO2
Molecular Weight	267.48 g/mol
Synonyms	Methyl 3-Bromo-6-chloro-2-fluorobenzoate; 3-Bromo-6-chloro-2-fluorobenzoic Acid Methyl Ester; Benzoic acid, 3-bromo-6-chloro-2-fluoro-, methyl ester; Methyl 3-bromo-6-chloro-2-fluorobenzoate; 1543224-54-9; Methyl 2-fluoro-3-bromo-6-chlorobenzoate
EINECS	Contact for details

Quality Control

Every batch of Methyl3-Bromo-6-Chloro-2-Fluorobenzoate is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) are provided with each shipment, detailing all relevant specifications. We adhere to cGMP principles for pharmaceutical-grade intermediates, ensuring traceability and documentation for regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed to prevent moisture absorption and contamination. Store away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.