Description

2-Bromo-5-Chloro-3-Fluorobenzoic Acid is a high-purity, multi-halogenated benzoic acid derivative serving as a critical building block in advanced organic synthesis. Its unique halogen substitution pattern makes it an invaluable intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and pesticides, where the halogen atoms contribute to bioactivity and environmental stability.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of monomers for specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Biology Probes: Useful for incorporating halogen tags into molecules for use in imaging, proteomics, and diagnostic assay development.
• Custom Synthesis and Contract Manufacturing: A fundamental reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences market.

Basic Information

Product Name	2-Bromo-5-Chloro-3-Fluorobenzoic Acid
CAS No.	1529288-48-9
Molecular Formula	C7H3BrClFO2
Molecular Weight	253.45 g/mol
Synonyms	5-Chloro-3-fluoro-2-bromobenzoic acid; 2-Bromo-5-chloro-3-fluorobenzoic acid; Benzoic acid, 2-bromo-5-chloro-3-fluoro-; 1529288-48-9; 3-Fluoro-2-bromo-5-chlorobenzoic acid
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-5-Chloro-3-Fluorobenzoic Acid is manufactured and tested under a strict quality management system. We guarantee high chemical purity and lot-to-lot consistency to meet the exacting standards of process chemistry and regulatory filings. Comprehensive analytical testing, including HPLC, NMR, and MS, is performed. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and away from direct light sources to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Purity (HPLC, Area%)	≥99.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.