Description

Methyl 6-Bromo-2,3,4-Trifluorobenzoate is a high-purity fluorinated aromatic building block essential for advanced organic synthesis. This compound is valued for its unique combination of bromine and fluorine substituents, which enable precise functionalization and derivatization in complex molecular architectures. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries to create novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring fluorinated aromatic cores for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Serves as a versatile building block for developing new herbicides, fungicides, and insecticides, where the fluorine atoms improve lipophilicity and target binding.
• Material Science Research: Used in the development of advanced organic electronic materials, such as semiconductors and liquid crystals, due to its electron-withdrawing properties.
• Cross-Coupling Reactions: The bromine atom acts as an excellent handle for palladium-catalyzed reactions like Suzuki, Stille, or Buchwald-Hartwig amination, enabling rapid diversification.
• Fluorine Chemistry Studies: An important substrate for investigating nucleophilic aromatic substitution (SNAr) and other reactions specific to polyfluorinated arenes.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring specific fluorinated motifs.

Basic Information

Product Name	Methyl 6-Bromo-2,3,4-Trifluorobenzoate
CAS No.	1525649-77-7
Molecular Formula	C8H4BrF3O2
Molecular Weight	277.02 g/mol
Synonyms	6-Bromo-2,3,4-trifluorobenzoic acid methyl ester; Methyl 6-bromo-2,3,4-trifluorobenzoate; Benzoic acid, 6-bromo-2,3,4-trifluoro-, methyl ester; 2,3,4-Trifluoro-6-bromobenzoic acid methyl ester; Methyl 2,3,4-trifluoro-6-bromobenzoate
EINECS	Contact for details

Quality Control

Our Methyl 6-Bromo-2,3,4-Trifluorobenzoate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The compound should be kept under an inert atmosphere for long-term storage to maintain optimal purity. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.