Description

2-Bromo-5-Chloro-4-Fluoro-Benzoic Acid Methyl Ester is a high-purity, multi-halogenated aromatic building block of significant importance in advanced organic synthesis. Its unique substitution pattern makes it a critical intermediate for constructing complex molecules, particularly in the pharmaceutical and agrochemical sectors. This compound is primarily sought after by R&D chemists and process development scientists working on active pharmaceutical ingredients (APIs), crop protection agents, and advanced materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially in medicinal chemistry programs targeting kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, leveraging its halogenated structure for bioactivity.
• Material Science Research: Serves as a precursor for liquid crystals, organic semiconductors, and other functional materials requiring specific halogenated aromatic cores.
• Chemical Reference Standard: Employed as an analytical standard in quality control laboratories for method development and validation.
• Custom Synthesis & Contract Manufacturing: A versatile starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences industry.

Basic Information

Product Name	2-Bromo-5-Chloro-4-Fluoro-Benzoic Acid Methyl Ester
CAS No.	1502835-28-0
Molecular Formula	C8H5BrClFO2
Molecular Weight	267.48 g/mol
Synonyms	Methyl 2-Bromo-5-Chloro-4-Fluorobenzoate; 2-Bromo-5-Chloro-4-Fluorobenzoic Acid Methyl Ester; Benzoic acid, 2-bromo-5-chloro-4-fluoro-, methyl ester; Methyl 2-Bromo-5-Chloro-4-Fluoro-Benzoate; 2-Bromo-5-chloro-4-fluorobenzoic acid methyl ester; Methyl (2-bromo-5-chloro-4-fluorophenyl)formate
EINECS	Contact for details

Quality Control

Every batch of our 2-Bromo-5-Chloro-4-Fluoro-Benzoic Acid Methyl Ester is produced and tested under a strict quality management system. We ensure compliance with relevant industry standards and provide comprehensive analytical documentation. A detailed Certificate of Analysis (COA) is available for each lot, confirming identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible organic solvents. For long-term storage, consider inert atmosphere conditions to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.