Description

2'2'-Cgamp is a specialized cyclic dinucleotide analog, a high-purity biochemical reagent with the CAS registry number 1465774-27-9. This compound is a critical tool in advanced life science research, particularly for studying intracellular signaling pathways and immune system activation. It is essential for researchers and developers in the fields of immunology, oncology, and vaccine adjuvants who require reliable, high-quality agonists for the cGAS-STING pathway.

Application

• STING Pathway Agonist Research: A potent and selective activator for studying the cGAS-STING signaling cascade in innate immunity.
• Cancer Immunotherapy Development: Used in preclinical research to evaluate novel immunotherapeutic strategies and cancer vaccine adjuvants.
• Virology and Infectious Disease Studies: Employed to model host antiviral defense mechanisms and inflammatory responses.
• Biochemical Assay Standard: Serves as a reference standard in HPLC, LC-MS, and other analytical methods for quality control and method validation.
• Pharmaceutical Intermediate: A key building block in the synthesis of more complex nucleotide-based therapeutic candidates.
• Cell Culture & In Vitro Studies: Used to stimulate interferon production and other cytokine responses in various immune cell lines.

Basic Information

Product Name	2'2'-Cgamp
CAS No.	1465774-27-9
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	2'2'-cyclic GMP-AMP; 2',2'-cGAMP; 2'2'-cyclic guanosine monophosphate–adenosine monophosphate; Cyclic [G(2',5')pA(3',5')p]; STING Agonist; cGAS-STING pathway activator; Cyclic dinucleotide; 1465774-27-9
EINECS	Contact for details

Quality Control

Our 2'2'-Cgamp is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via mass spectrometry, to ensure it meets the exacting standards required for research and development. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature before opening to minimize moisture absorption. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥95%
Water Content (KF)	≤5.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.